Cerebral glucose utilization in human heroin addicts: Case reports from a positron emission tomographic study

E. D. London; R. A. Margolin; D. F. Wong; J. Links; N. D. La France; N. G. Cascella; E. P.M. Broussolle; H. N. Wagner; F. R. Snyder; D. R. Jasinski

Cerebral glucose utilization in human heroin addicts: Case reports from a positron emission tomographic study

E. D. London, R. A. Margolin, D. F. Wong, J. Links, N. D. La France, N. G. Cascella, E. P.M. Broussolle, H. N. Wagner, F. R. Snyder, D. R. Jasinski

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Regional and global cerebral metabolic rates for glucose (rCMRglu, CMRglu) were assayed in two active heroin addicts and three post-addicts by the [¹⁸F]fluorodeoxyglucose (FDG) positron emission tomographic (PET) method. Self-reports on the Morphine-Benzedrine Group (MBG) scale of the Addiction Research Center Inventory (ARCI) indicated no effect of heroin on mood in subject #1, but a strong effect in subject #2. Compared with postaddicts, subject #1 showed fewer differences in rCMRglu than subject #2. Metabolic rates in subject #1 were lower in the cuneus, gyrus rectus, and cerebellum, but higher in the amygdala-hippocampus than in postaddicts; CMRglu was not changed. Subject #2 showed lower CMRglu and rCMRglu in areas of visual cortex, the basal ganglia and hippocampal formation. The findings suggest that chronic heroin can produce persistent deficits in telencephalic rCMRglu, which may relate to effects on mood.

Original language	English (US)
Pages (from-to)	141-144
Number of pages	4
Journal	Research Communications in Substances of Abuse
Volume	10
Issue number	2
State	Published - 1989

ASJC Scopus subject areas

Medicine (miscellaneous)

Cite this

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title = "Cerebral glucose utilization in human heroin addicts: Case reports from a positron emission tomographic study",

abstract = "Regional and global cerebral metabolic rates for glucose (rCMRglu, CMRglu) were assayed in two active heroin addicts and three post-addicts by the [18F]fluorodeoxyglucose (FDG) positron emission tomographic (PET) method. Self-reports on the Morphine-Benzedrine Group (MBG) scale of the Addiction Research Center Inventory (ARCI) indicated no effect of heroin on mood in subject #1, but a strong effect in subject #2. Compared with postaddicts, subject #1 showed fewer differences in rCMRglu than subject #2. Metabolic rates in subject #1 were lower in the cuneus, gyrus rectus, and cerebellum, but higher in the amygdala-hippocampus than in postaddicts; CMRglu was not changed. Subject #2 showed lower CMRglu and rCMRglu in areas of visual cortex, the basal ganglia and hippocampal formation. The findings suggest that chronic heroin can produce persistent deficits in telencephalic rCMRglu, which may relate to effects on mood.",

author = "London, {E. D.} and Margolin, {R. A.} and Wong, {D. F.} and J. Links and {La France}, {N. D.} and Cascella, {N. G.} and Broussolle, {E. P.M.} and Wagner, {H. N.} and Snyder, {F. R.} and Jasinski, {D. R.}",

year = "1989",

language = "English (US)",

volume = "10",

pages = "141--144",

journal = "Research Communications in Substances of Abuse",

issn = "0193-0818",

publisher = "PJD Publications Ltd",

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TY - JOUR

T1 - Cerebral glucose utilization in human heroin addicts

T2 - Case reports from a positron emission tomographic study

AU - London, E. D.

AU - Margolin, R. A.

AU - Wong, D. F.

AU - Links, J.

AU - La France, N. D.

AU - Cascella, N. G.

AU - Broussolle, E. P.M.

AU - Wagner, H. N.

AU - Snyder, F. R.

AU - Jasinski, D. R.

PY - 1989

Y1 - 1989

N2 - Regional and global cerebral metabolic rates for glucose (rCMRglu, CMRglu) were assayed in two active heroin addicts and three post-addicts by the [18F]fluorodeoxyglucose (FDG) positron emission tomographic (PET) method. Self-reports on the Morphine-Benzedrine Group (MBG) scale of the Addiction Research Center Inventory (ARCI) indicated no effect of heroin on mood in subject #1, but a strong effect in subject #2. Compared with postaddicts, subject #1 showed fewer differences in rCMRglu than subject #2. Metabolic rates in subject #1 were lower in the cuneus, gyrus rectus, and cerebellum, but higher in the amygdala-hippocampus than in postaddicts; CMRglu was not changed. Subject #2 showed lower CMRglu and rCMRglu in areas of visual cortex, the basal ganglia and hippocampal formation. The findings suggest that chronic heroin can produce persistent deficits in telencephalic rCMRglu, which may relate to effects on mood.

AB - Regional and global cerebral metabolic rates for glucose (rCMRglu, CMRglu) were assayed in two active heroin addicts and three post-addicts by the [18F]fluorodeoxyglucose (FDG) positron emission tomographic (PET) method. Self-reports on the Morphine-Benzedrine Group (MBG) scale of the Addiction Research Center Inventory (ARCI) indicated no effect of heroin on mood in subject #1, but a strong effect in subject #2. Compared with postaddicts, subject #1 showed fewer differences in rCMRglu than subject #2. Metabolic rates in subject #1 were lower in the cuneus, gyrus rectus, and cerebellum, but higher in the amygdala-hippocampus than in postaddicts; CMRglu was not changed. Subject #2 showed lower CMRglu and rCMRglu in areas of visual cortex, the basal ganglia and hippocampal formation. The findings suggest that chronic heroin can produce persistent deficits in telencephalic rCMRglu, which may relate to effects on mood.

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M3 - Article

AN - SCOPUS:0024401198

SN - 0193-0818

VL - 10

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JO - Research Communications in Substances of Abuse

JF - Research Communications in Substances of Abuse

IS - 2

ER -

Cerebral glucose utilization in human heroin addicts: Case reports from a positron emission tomographic study

Abstract

ASJC Scopus subject areas

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