Abstract
It was shown in the present study that several structurally diverse antagonists of the glycine site of the NMDA receptor, including (R)-HA-966, L 689,560, 5,7-dichlorokynurenic acid, 7-chlorokynurenic acid, and two of ZENECA's novel pyridazinoindole glycine antagonists, caused marked reversal of akinesia when administered intrastriatally to monoamine depleted mice. Coinjection of the glycine agonist D-serine antagonized this locomotor stimulation. In addition, all glycine antagonists tested did not cause significant locomotor stimulation when intrastriatally administered to normal mice. These data suggest that glycine antagonists may offer therapeutic utility in the treatment of idiopathic Parkinson's disease.
Original language | English (US) |
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Pages (from-to) | 175-185 |
Number of pages | 11 |
Journal | Journal of Neural Transmission |
Volume | 97 |
Issue number | 3 |
DOIs | |
State | Published - Oct 1994 |
Externally published | Yes |
Keywords
- NMDA receptors
- Parkinson's disease
- Reserpine
- alpha-methyl-para-tyrosine
- dopamine
- glutamate
- glycine
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry