Central vs peripheral anticholinergic effects on repeated acquisition of behavioral chains

Aharon Levy; Timothy F. Elsmore; Steven R. Hursh

doi:10.1016/S0163-1047(84)90122-5

Central vs peripheral anticholinergic effects on repeated acquisition of behavioral chains

Aharon Levy, Timothy F. Elsmore, Steven R. Hursh

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Monkeys that were required to repeatedly learn new sequences of responses to obtain food were injected with 0.2 mg/kg of atropine sulfate or methylatropine nitrate. Effects lasted 8 to 12 hr following injection. Both drugs decreased the rate at which the animals worked, but only atropine sulfate increased the number of attempts required to solve the problem and decreased overall accuracy, suggesting a peripheral mode of action for rate-decreasing effects, and a central mode of action for effects of atropine on qualitative aspects of performance.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Behavioral and Neural Biology
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/S0163-1047(84)90122-5
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Physiology

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AU - Hursh, Steven R.

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AB - Monkeys that were required to repeatedly learn new sequences of responses to obtain food were injected with 0.2 mg/kg of atropine sulfate or methylatropine nitrate. Effects lasted 8 to 12 hr following injection. Both drugs decreased the rate at which the animals worked, but only atropine sulfate increased the number of attempts required to solve the problem and decreased overall accuracy, suggesting a peripheral mode of action for rate-decreasing effects, and a central mode of action for effects of atropine on qualitative aspects of performance.

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Central vs peripheral anticholinergic effects on repeated acquisition of behavioral chains

Abstract

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