Central pontine myelinolysis and medullary myelinolysis.

B. S. Bhagavan, J. A. Wagner, J. Juanteguy

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Central pontine myelinolysis (CPM) is a rare, acute, and uniformly fatal demyelinative process that involves the pons almost exclusively. Three cases diagnosed at autopsy illustrate the characteristic clinical course and pathologic features of CPM. A unique extrapontine location of a similar process is noted in the medulla of a 6-year-old girl. The term "medullary myelinolysis" is a descriptive designation for demyelination that occurs predominantly in this area. The clinical and pathologic features of CPM are reviewed in detail, together with a brief review of theories of metabolic, nutritional, vascular, and endogenous and exogenous toxic factors that act either singly or in concert in the cause and pathogenesis of CPM.

Original languageEnglish (US)
Pages (from-to)246-252
Number of pages7
JournalArchives of Pathology and Laboratory Medicine
Issue number5
StatePublished - May 1976
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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