Central nervous system germ cell tumors

M. Adelita Vizcaino, Fausto J. Rodriguez

Research output: Chapter in Book/Report/Conference proceedingChapter


The central nervous system is one of the most frequent sites of involvement by extragonadal germ cell tumors. Most of these occur in midline structures, particularly in the sellar region and pineal gland, as well as other sites to a lesser extent (e.g., basal ganglia). The predominant histologic type is germinoma, the intracranial counterpart to the seminoma in the testis and dysgerminoma in the ovary. As in these other sites, germinoma has an exquisite sensitivity to current treatment and an improved prognosis compared to other germ cell tumor components, all of which may occur in the nervous system. Clinical evaluation of these patients involves neuroimaging and analysis of markers in serum and cerebrospinal fluid for diagnosis and to monitor relapse. Recent sequencing efforts have expanded our knowledge of the biology of these tumors and uncovered a high frequency of somatic mutations in members of the KIT/RAS pathways and mTOR/AKT to a lesser extent, in intracranial germ cell tumors, particularly germinoma. In this review we summarize our current knowledge about the clinicopathologic, phenotypic, and molecular characteristics of intracranial germ cell tumors, highlighting specific properties to intracranial sites.

Original languageEnglish (US)
Title of host publicationPathology and Biology of Human Germ Cell Tumors
PublisherSpringer Berlin Heidelberg
Number of pages15
ISBN (Electronic)9783662537756
ISBN (Print)9783662537732
StatePublished - Jan 1 2017


  • Brain
  • Central nervous system
  • Germinoma
  • Non-germinomatous germ cell tumors
  • Pineal
  • Pituitary
  • Sellar

ASJC Scopus subject areas

  • General Medicine


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