Central nervous system cancers Clinical Practice Guidelines in Oncology

Steven S. Brem, Philip J. Bierman, Peter Black, Deborah T. Blumenthal, Henry Brem, Marc C. Chamberlain, Ennio A. Chiocca, Lisa M. DeAngelis, Robert A. Fenstermaker, Howard A. Fine, Allan Friedman, Jon Glass, Stuart A. Grossman, Amy B. Heimberger, Larry Junck, Victor Levin, Jay J. Loeffler, Moshe H. Maor, Ashwatha Narayana, Herbert B. NewtonAlessandro Olivi, Jana Portnow, Michael Prados, Jeffrey J. Raizer, Steven S. Rosenfeld, Dennis C. Shrieve, Allen K. Sills, Alexander M. Spence, Frank D. Vrionis

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


In the year 2005, an estimated 18,500 new cases of primary brain and nervous system neoplasms will be diagnosed in the United States. These tumors will be responsible for approximately 12,760 deaths. The incidence of primary malignant brain tumors has been increasing over the past 25 years, especially in elderly persons (rates are increasing at about 1.2% each year). Metastatic disease to the central nervous system (CNS) occurs much more frequently, with an incidence about 10 times that of primary brain tumors. It is estimated between 20% and 40% of patients with systemic cancer will develop brain metastases.

Original languageEnglish (US)
Pages (from-to)644-690
Number of pages47
JournalJNCCN Journal of the National Comprehensive Cancer Network
Issue number5
StatePublished - Sep 2005


  • Astrocytoma
  • Brain metastases
  • Brain tumor
  • Chemotherapy
  • Glioblastoma
  • NCCN Clinical Practice Guidelines
  • Spinal metastases
  • Temozolomide

ASJC Scopus subject areas

  • Oncology


Dive into the research topics of 'Central nervous system cancers Clinical Practice Guidelines in Oncology'. Together they form a unique fingerprint.

Cite this