TY - JOUR
T1 - Central fixation detection with an open-frame retinal birefringence scanning system
T2 - Optics, optomechanics, polarization balancing aspects, computer modeling and simulation
AU - Gramatikov, Boris
AU - Irsch, Kristina
AU - Guyton, David
N1 - Funding Information:
This project was supported partially by the Individual Biomedical Research Award from The Hartwell Foundation ; a Collaboration Research Award from The Hartwell Foundation; generous gifts from Robert and Maureen Feduniak, Dewey and Janet Gargiulo, David and Helen Leighton, Richard and Victoria Baks, and Robert and Diane Levy.
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/8
Y1 - 2023/8
N2 - There is a growing need to add a fast fixation-detection system or even an eye-tracking system to various diagnostic and some therapeutic ophthalmic technologies. For example, this would enable registration of stable images of the fovea. In recent years we have developed rapid technologies that detect the location of the fovea using retinal birefringence scanning (RBS). Yet, combining it with ophthalmic imaging technologies is not trivial, mainly because RBS employs polarized light and polarization-sensitive optics, while most ophthalmic imaging systems do not. Therefore, integrating these two types of systems optically poses a significant challenge, especially to the RBS system. Using principles from polarization optics and Mueller-matrix-based computer modeling for optimization, we developed a prototype of an open-frame RBS system as a potential adjunct fixation monitoring technology, with a promise to reduce the interference created by eye movements in advanced ophthalmic imaging technologies, such as optical coherence tomography, fluorescein angiography, scanning laser ophthalmoscopy, and others. Our technology is fast, does not need calibration, and uses true anatomical information from the retina for fixation detection. It enables adding fixation monitoring capabilities without having to modify the main imaging system, and has the potential to facilitate imaging without anesthesia in otherwise challenging subjects and/or patients, such as young children.
AB - There is a growing need to add a fast fixation-detection system or even an eye-tracking system to various diagnostic and some therapeutic ophthalmic technologies. For example, this would enable registration of stable images of the fovea. In recent years we have developed rapid technologies that detect the location of the fovea using retinal birefringence scanning (RBS). Yet, combining it with ophthalmic imaging technologies is not trivial, mainly because RBS employs polarized light and polarization-sensitive optics, while most ophthalmic imaging systems do not. Therefore, integrating these two types of systems optically poses a significant challenge, especially to the RBS system. Using principles from polarization optics and Mueller-matrix-based computer modeling for optimization, we developed a prototype of an open-frame RBS system as a potential adjunct fixation monitoring technology, with a promise to reduce the interference created by eye movements in advanced ophthalmic imaging technologies, such as optical coherence tomography, fluorescein angiography, scanning laser ophthalmoscopy, and others. Our technology is fast, does not need calibration, and uses true anatomical information from the retina for fixation detection. It enables adding fixation monitoring capabilities without having to modify the main imaging system, and has the potential to facilitate imaging without anesthesia in otherwise challenging subjects and/or patients, such as young children.
KW - Computer modeling of polarization-sensitive systems
KW - Conjoined ophthalmic systems
KW - Fast central fixation detection
KW - Ophthalmic optics
KW - Polarization-responsive retinal scanning
KW - Retinal birefringence
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U2 - 10.1016/j.optlastec.2023.109388
DO - 10.1016/j.optlastec.2023.109388
M3 - Article
AN - SCOPUS:85150857670
SN - 0030-3992
VL - 163
JO - Optics and Laser Technology
JF - Optics and Laser Technology
M1 - 109388
ER -