TY - JOUR
T1 - Cellular stage specific functional analysis of REX1
T2 - In human embryonic stem cells
AU - Kim, Yong Jun
AU - Lee, Gabsang
N1 - Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - As transcription and translation are dynamic and can vary among the cell types and conditions, proteomics may reveal the tissue-specific functions of a protein, more relevant to its genuine functions on cellular mechanisms. The new proteome analysis by Son et al. [Proteomics 2015, 15, 2220-2229] identified the functions of the pluripotency marker protein, REX1 in hESCs, and unraveling its regulatory network orchestrating pluripotency. Compared to the previous transcriptome analysis that showed mechanisms irrelevant to pluripotency, Son et al. employed a proteome analysis determined convincing and meaningful mechanisms of REX. In addition to demonstrating the biological importance of REX1, this research by Son et al. is also a compelling example of the conceptual significance of connecting proteomics with stem cell biology.
AB - As transcription and translation are dynamic and can vary among the cell types and conditions, proteomics may reveal the tissue-specific functions of a protein, more relevant to its genuine functions on cellular mechanisms. The new proteome analysis by Son et al. [Proteomics 2015, 15, 2220-2229] identified the functions of the pluripotency marker protein, REX1 in hESCs, and unraveling its regulatory network orchestrating pluripotency. Compared to the previous transcriptome analysis that showed mechanisms irrelevant to pluripotency, Son et al. employed a proteome analysis determined convincing and meaningful mechanisms of REX. In addition to demonstrating the biological importance of REX1, this research by Son et al. is also a compelling example of the conceptual significance of connecting proteomics with stem cell biology.
KW - Human embryonic stem cells
KW - REX1
UR - http://www.scopus.com/inward/record.url?scp=84933574197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84933574197&partnerID=8YFLogxK
U2 - 10.1002/pmic.201500208
DO - 10.1002/pmic.201500208
M3 - Comment/debate
C2 - 26058466
AN - SCOPUS:84933574197
SN - 1615-9853
VL - 15
SP - 2147
EP - 2149
JO - Proteomics
JF - Proteomics
IS - 13
ER -