TY - JOUR
T1 - Cellular localization of a metabotropic glutamate receptor in rat brain
AU - Martin, Lee J.
AU - Blackstone, Craig D.
AU - Huganir, Richard L.
AU - Price, Donald L.
N1 - Funding Information:
The authors thank Dr. Clark Riley and The Howard Hughes Medical Institute Biopolymer Laboratory for the preparation of synthetic peptide. Wealso thank Ms. JudithVan Lareand Mr. Wayne Voris for their excellent technical assistance. Thisworkwassupported bygrantsfromtheU.S.PublicHealth Service (National lnstititutes of Health NS20471 and AG05146), the Medical Scientist Training Program (GM07309), and The Howard Hughes Medical Institute and funds from the American Health Assistance Foundation and The Metropolitan Life Foundation. D. L. P. is the recipient of a Leadership and Excellence in Alzheimer’s Disease (LEAD) award (NIAAG07914) and a Javits Neuroscience Investigator award (NIH NS 10580). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked ‘adverfisemenf” in accordance with 18 USC Section 1734 solely to indicate fact.
PY - 1992/8
Y1 - 1992/8
N2 - In rat brain, the cellular localization of a phosphoinositide-linked metabotropic glutamate receptor (mGluR1α) was demonstrated using antibodies that recognize the C-terminus of the receptor. mGluR1α, a 142 kd protein, is enriched within the olfactory bulb, stratum oriens of CA1 and polymorph layer of dentate gyrus in hippocampus, globus pallidus, thalamus, substantia nigra, superior colliculus, and cerebellum. Lower levels of mGluR1α are present within neocortex, striatum, amygdala, hypothalamus, and medulla. Dendrites, spines, and neuronal cell bodies contain mGluR1α. mG1uR1α is not detectable in presynaptic terminals. mGluR1α and ionotropic a-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits show differential distributions, but in Purkinje cells, mGluR1α and specific AMPA receptor subunits colocalize. The postsynaptic distribution of mGluR1α is consistent with postulated physiological roles of this subtype of glutamate receptor.
AB - In rat brain, the cellular localization of a phosphoinositide-linked metabotropic glutamate receptor (mGluR1α) was demonstrated using antibodies that recognize the C-terminus of the receptor. mGluR1α, a 142 kd protein, is enriched within the olfactory bulb, stratum oriens of CA1 and polymorph layer of dentate gyrus in hippocampus, globus pallidus, thalamus, substantia nigra, superior colliculus, and cerebellum. Lower levels of mGluR1α are present within neocortex, striatum, amygdala, hypothalamus, and medulla. Dendrites, spines, and neuronal cell bodies contain mGluR1α. mG1uR1α is not detectable in presynaptic terminals. mGluR1α and ionotropic a-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits show differential distributions, but in Purkinje cells, mGluR1α and specific AMPA receptor subunits colocalize. The postsynaptic distribution of mGluR1α is consistent with postulated physiological roles of this subtype of glutamate receptor.
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U2 - 10.1016/0896-6273(92)90165-A
DO - 10.1016/0896-6273(92)90165-A
M3 - Article
C2 - 1323311
AN - SCOPUS:0026794813
SN - 0896-6273
VL - 9
SP - 259
EP - 270
JO - Neuron
JF - Neuron
IS - 2
ER -