Cellular Immune Status in Retinitis Pigmentosa

Previous reports have suggested a role of cellular and/or humoral immunity in retinitis pigmentosa. Because of the controversial nature of many of these reports, the authors undertook a detailed investigation of cellular and humoral immunity in a well-characterized group of 47 persons with retinitis pigmentosa of various heritability patterns and a similar number of age- and sexmatched controls. The authors found two changes in lymphocyte subsets. Retinitis pigmentosa patients had significantly elevated Leu 3A-positive lymphocytes (CD4 or T-helper cells) and significantly fewer Leu 2A-positive lymphocytes (CD8 or T-suppressor cells) than controls, although the total numbers of T cells did not differ between the two groups. A small but significant number of retinitis pigmentosa patients expressed interleukin 2 (IL-2) antigens on their lymphocytes as compared with none of the controls. The authors saw no differences between the retinitis pigmentosa and control groups in the inducibility and secretion of gamma-interferon or IL-2. Concentrations of immunoglobulins G, A, and M did not differ between the two groups. The link between immune system alterations and the retinitis pigmentosa process remains tenuous.