Cellular immune responses during complicated and uncomplicated measles virus infections of man

Robert L. Hirsch; Diane E. Griffin; Richard T. Johnson; Susan J. Cooper; Imelda Lindo de Soriano; Susi Roedenbeck; Abraham Vaisberg

doi:10.1016/0090-1229(84)90184-3

Cellular immune responses during complicated and uncomplicated measles virus infections of man

Robert L. Hirsch, Diane E. Griffin, Richard T. Johnson, Susan J. Cooper, Imelda Lindo de Soriano, Susi Roedenbeck, Abraham Vaisberg

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

Lymphocytes from patients with measles showed profound and prolonged suppression of proliferative responses to mitogens. The degree of suppression was similar in patients with uncomplicated measles virus infection and in those with pneumonia or postinfectious encephalitis. Despite this suppression, lymphocyte responses to measles antigen and PPD were demonstrated in patients with encephalitis and uncomplicated disease, even early in infection. Most patients with pneumonia did not have demonstrable antigen-specific responses. The proportions of T helper (OKT 4) and T suppressor (OKT 8) cells and functional tests of Con A suppressor cell activity showed no significant difference between control and measles patients but, in contrast to controls, cells from measles patients cultured in the absence of any stimulant significantly suppressed the proliferation of allogeneic responder cells. Nine of 20 supernatant fluids from these cultures possessed a soluble suppressor factor. These studies indicate varied disruptions of immune reactivity during measles.

Original language	English (US)
Pages (from-to)	1-12
Number of pages	12
Journal	Clinical Immunology and Immunopathology
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/0090-1229(84)90184-3
State	Published - Apr 1984

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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10.1016/0090-1229(84)90184-3

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@article{1339b704abba4bb0a2fb0f3fedd2149b,

title = "Cellular immune responses during complicated and uncomplicated measles virus infections of man",

abstract = "Lymphocytes from patients with measles showed profound and prolonged suppression of proliferative responses to mitogens. The degree of suppression was similar in patients with uncomplicated measles virus infection and in those with pneumonia or postinfectious encephalitis. Despite this suppression, lymphocyte responses to measles antigen and PPD were demonstrated in patients with encephalitis and uncomplicated disease, even early in infection. Most patients with pneumonia did not have demonstrable antigen-specific responses. The proportions of T helper (OKT 4) and T suppressor (OKT 8) cells and functional tests of Con A suppressor cell activity showed no significant difference between control and measles patients but, in contrast to controls, cells from measles patients cultured in the absence of any stimulant significantly suppressed the proliferation of allogeneic responder cells. Nine of 20 supernatant fluids from these cultures possessed a soluble suppressor factor. These studies indicate varied disruptions of immune reactivity during measles.",

author = "Hirsch, {Robert L.} and Griffin, {Diane E.} and Johnson, {Richard T.} and Cooper, {Susan J.} and {de Soriano}, {Imelda Lindo} and Susi Roedenbeck and Abraham Vaisberg",

note = "Funding Information: We appreciate the assitance given by Professor Hugo Lumbreras and Professor Humberto Guerra and their staffat the Instituto de Medicina Tropical Alexander von Humboldt, and by students Ernest0 Bancalari and Nicki Silva. This study was supported by grants from the Kroc Foundation, the Rockefeller Foundation and NS 15721 from the National Institutes of Health. Data analysis was aided by Clinfo (5MOl RR 3520).",

year = "1984",

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doi = "10.1016/0090-1229(84)90184-3",

language = "English (US)",

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T1 - Cellular immune responses during complicated and uncomplicated measles virus infections of man

AU - Hirsch, Robert L.

AU - Griffin, Diane E.

AU - Johnson, Richard T.

AU - Cooper, Susan J.

AU - de Soriano, Imelda Lindo

AU - Roedenbeck, Susi

AU - Vaisberg, Abraham

N1 - Funding Information: We appreciate the assitance given by Professor Hugo Lumbreras and Professor Humberto Guerra and their staffat the Instituto de Medicina Tropical Alexander von Humboldt, and by students Ernest0 Bancalari and Nicki Silva. This study was supported by grants from the Kroc Foundation, the Rockefeller Foundation and NS 15721 from the National Institutes of Health. Data analysis was aided by Clinfo (5MOl RR 3520).

PY - 1984/4

Y1 - 1984/4

N2 - Lymphocytes from patients with measles showed profound and prolonged suppression of proliferative responses to mitogens. The degree of suppression was similar in patients with uncomplicated measles virus infection and in those with pneumonia or postinfectious encephalitis. Despite this suppression, lymphocyte responses to measles antigen and PPD were demonstrated in patients with encephalitis and uncomplicated disease, even early in infection. Most patients with pneumonia did not have demonstrable antigen-specific responses. The proportions of T helper (OKT 4) and T suppressor (OKT 8) cells and functional tests of Con A suppressor cell activity showed no significant difference between control and measles patients but, in contrast to controls, cells from measles patients cultured in the absence of any stimulant significantly suppressed the proliferation of allogeneic responder cells. Nine of 20 supernatant fluids from these cultures possessed a soluble suppressor factor. These studies indicate varied disruptions of immune reactivity during measles.

AB - Lymphocytes from patients with measles showed profound and prolonged suppression of proliferative responses to mitogens. The degree of suppression was similar in patients with uncomplicated measles virus infection and in those with pneumonia or postinfectious encephalitis. Despite this suppression, lymphocyte responses to measles antigen and PPD were demonstrated in patients with encephalitis and uncomplicated disease, even early in infection. Most patients with pneumonia did not have demonstrable antigen-specific responses. The proportions of T helper (OKT 4) and T suppressor (OKT 8) cells and functional tests of Con A suppressor cell activity showed no significant difference between control and measles patients but, in contrast to controls, cells from measles patients cultured in the absence of any stimulant significantly suppressed the proliferation of allogeneic responder cells. Nine of 20 supernatant fluids from these cultures possessed a soluble suppressor factor. These studies indicate varied disruptions of immune reactivity during measles.

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Cellular immune responses during complicated and uncomplicated measles virus infections of man

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