Cellular gene therapy

J. H. Lee, H. G. Klein

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


During the last decade, molecular genetic techniques have been used increasingly to transfer human genes into mammalian cells, to correct and enhance cell function, and finally to treat human disease. Despite the current obstacles to developing even the simplest therapeutic strategy, gene therapy promises to have an almost unlimited future. The ability to collect specific blood cells in large numbers, to manipulate their expansion, growth, and differentiation in vitro, and also to cryopreserve these cells for later use has been central to the early developments in gene therapy. This article reviews the major concepts involved in blood cell-based gene therapy, a model for all somatic cell gene therapy.

Original languageEnglish (US)
Pages (from-to)91-113
Number of pages23
JournalHematology/Oncology Clinics of North America
Issue number1
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Hematology


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