Cellular basis of the genetic control of immune responsiveness to murine thyroglobulin in mice

A. O. Vladutiu; N. R. Rose

doi:10.1016/S0008-8749(75)80010-4

Cellular basis of the genetic control of immune responsiveness to murine thyroglobulin in mice

A. O. Vladutiu, N. R. Rose

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Cell transfer experiments were performed to determine the role of T and B lymphocytes in the genetic control of autoimmune thyroiditis. Adult female BALB/c mice H-2^d), poor responders, were thymectomized, lethally irradiated, and reconstituted with T lymphocytes (thymus cell suspensions), B lymphocytes (bone marrow cells treated with anti-θ serum and complement), or T and B lymphocytes from (RF × BALB/c)F₁ good responder mice. Chimeras were immunized with homologous thyroglobulin, and the thyroid antibody and pathology index were assessed. T lymphocytes but not B lymphocytes could transfer responsiveness to thyroglobulin. Adult thymectomized mice had a markedly decreased immune response to thyroglobulin. Homozygous nude (nu/nu) mice did not develop thyroiditis in contrast to heterozygous (nu/+) littermates.

Original language	English (US)
Pages (from-to)	106-113
Number of pages	8
Journal	Cellular Immunology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/S0008-8749(75)80010-4
State	Published - May 1975
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/S0008-8749(75)80010-4

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title = "Cellular basis of the genetic control of immune responsiveness to murine thyroglobulin in mice",

abstract = "Cell transfer experiments were performed to determine the role of T and B lymphocytes in the genetic control of autoimmune thyroiditis. Adult female BALB/c mice H-2d), poor responders, were thymectomized, lethally irradiated, and reconstituted with T lymphocytes (thymus cell suspensions), B lymphocytes (bone marrow cells treated with anti-θ serum and complement), or T and B lymphocytes from (RF × BALB/c)F1 good responder mice. Chimeras were immunized with homologous thyroglobulin, and the thyroid antibody and pathology index were assessed. T lymphocytes but not B lymphocytes could transfer responsiveness to thyroglobulin. Adult thymectomized mice had a markedly decreased immune response to thyroglobulin. Homozygous nude (nu/nu) mice did not develop thyroiditis in contrast to heterozygous (nu/+) littermates.",

author = "Vladutiu, {A. O.} and Rose, {N. R.}",

note = "Funding Information: In the present experiments we studied the cellular mechanisms involved in the immune responsiveness to thyroglobulin by the technique of adoptive transfer. In i Supported in part by NIH Research Grant, CA02357, from the National Cancer Institute. A portion of the work described was carried out at the Center for Immunology, State 17ni-versity of New York at Buffalo.",

year = "1975",

month = may,

doi = "10.1016/S0008-8749(75)80010-4",

language = "English (US)",

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pages = "106--113",

journal = "Cellular Immunology",

issn = "0008-8749",

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T1 - Cellular basis of the genetic control of immune responsiveness to murine thyroglobulin in mice

AU - Vladutiu, A. O.

AU - Rose, N. R.

N1 - Funding Information: In the present experiments we studied the cellular mechanisms involved in the immune responsiveness to thyroglobulin by the technique of adoptive transfer. In i Supported in part by NIH Research Grant, CA02357, from the National Cancer Institute. A portion of the work described was carried out at the Center for Immunology, State 17ni-versity of New York at Buffalo.

PY - 1975/5

Y1 - 1975/5

N2 - Cell transfer experiments were performed to determine the role of T and B lymphocytes in the genetic control of autoimmune thyroiditis. Adult female BALB/c mice H-2d), poor responders, were thymectomized, lethally irradiated, and reconstituted with T lymphocytes (thymus cell suspensions), B lymphocytes (bone marrow cells treated with anti-θ serum and complement), or T and B lymphocytes from (RF × BALB/c)F1 good responder mice. Chimeras were immunized with homologous thyroglobulin, and the thyroid antibody and pathology index were assessed. T lymphocytes but not B lymphocytes could transfer responsiveness to thyroglobulin. Adult thymectomized mice had a markedly decreased immune response to thyroglobulin. Homozygous nude (nu/nu) mice did not develop thyroiditis in contrast to heterozygous (nu/+) littermates.

AB - Cell transfer experiments were performed to determine the role of T and B lymphocytes in the genetic control of autoimmune thyroiditis. Adult female BALB/c mice H-2d), poor responders, were thymectomized, lethally irradiated, and reconstituted with T lymphocytes (thymus cell suspensions), B lymphocytes (bone marrow cells treated with anti-θ serum and complement), or T and B lymphocytes from (RF × BALB/c)F1 good responder mice. Chimeras were immunized with homologous thyroglobulin, and the thyroid antibody and pathology index were assessed. T lymphocytes but not B lymphocytes could transfer responsiveness to thyroglobulin. Adult thymectomized mice had a markedly decreased immune response to thyroglobulin. Homozygous nude (nu/nu) mice did not develop thyroiditis in contrast to heterozygous (nu/+) littermates.

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Cellular basis of the genetic control of immune responsiveness to murine thyroglobulin in mice

Abstract

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