Cell cycle control, DNA damage checkpoints and cancer

Marikki Laiho, Leena Latonen

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


DNA damage checkpoints are essential control points in the cell cycle ensuring effective damage repair. The loss of checkpoint functions leads to loss of genomic integrity and allows accumulation of genetic damage in the daughter cells. Checkpoint deficiency is one of the main causes of DNA aberrations in cancer.

Original languageEnglish (US)
Pages (from-to)391-397
Number of pages7
JournalAnnals of Medicine
Issue number6
StatePublished - 2003
Externally publishedYes


  • Cancer syndromes
  • Cell cycle
  • DNA damage checkpoint
  • DNA repair

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Cell cycle control, DNA damage checkpoints and cancer'. Together they form a unique fingerprint.

Cite this