Cell cultures as models of cardiac mechanoelectric feedback

Yibing Zhang, Rajesh B. Sekar, Andrew D. McCulloch, Leslie Tung

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Although stretch-activated currents have been extensively studied in isolated cells and intact heart in the context of mechanoelectric feedback (MEF) in the heart, quantitative data regarding other mechanical parameters such as pressure, shear, bending, etc, are still lacking at the multicellular level. Cultured cardiac cell monolayers have been used increasingly in the past decade as an in vitro model for the studies of fundamental mechanisms that underlie normal and pathological electrophysiology at the tissue level. Optical mapping makes possible multisite recording and analysis of action potentials and wavefront propagation, suitable for monitoring the electrophysiological activity of the cardiac cell monolayer under a wide variety of controlled mechanical conditions. In this paper, we review methodologies that have been developed or could be used to mechanically perturb cell monolayers, and present some new results on the acute effects of pressure, shear stress and anisotropic strain on cultured neonatal rat ventricular myocyte (NRVM) monolayers.

Original languageEnglish (US)
Pages (from-to)367-382
Number of pages16
JournalProgress in Biophysics and Molecular Biology
Issue number2-3
StatePublished - Jun 2008


  • Anisotropic stretch
  • Cardiac cell monolayer
  • Electrophysiology
  • Mechanoelectrical feedback
  • Optical mapping
  • Pressure
  • Shear stress

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology


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