Cell biology of the ESCRT machinery

Phyllis I. Hanson, Soomin Shim, Samuel A. Merrill

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


The ESCRT (endosomal sorting complex required for transport) machinery comprises a set of protein complexes that regulate sorting and trafficking into multivesicular bodies en route to the lysosome. The physical mechanism responsible for generating lumenal vesicles in this pathway is unknown. Here we review recent studies suggesting that components of the ESCRT-III complex drive lumenal vesicle formation and consider possible mechanisms for this reaction.

Original languageEnglish (US)
Pages (from-to)568-574
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number4
StatePublished - Aug 2009
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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