Cell biology of the ESCRT machinery

Phyllis I. Hanson; Soomin Shim; Samuel A. Merrill

doi:10.1016/j.ceb.2009.06.002

Cell biology of the ESCRT machinery

Phyllis I. Hanson, Soomin Shim, Samuel A. Merrill

Research output: Contribution to journal › Review article › peer-review

71 Scopus citations

Abstract

The ESCRT (endosomal sorting complex required for transport) machinery comprises a set of protein complexes that regulate sorting and trafficking into multivesicular bodies en route to the lysosome. The physical mechanism responsible for generating lumenal vesicles in this pathway is unknown. Here we review recent studies suggesting that components of the ESCRT-III complex drive lumenal vesicle formation and consider possible mechanisms for this reaction.

Original language	English (US)
Pages (from-to)	568-574
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.ceb.2009.06.002
State	Published - Aug 2009
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2009.06.002

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title = "Cell biology of the ESCRT machinery",

abstract = "The ESCRT (endosomal sorting complex required for transport) machinery comprises a set of protein complexes that regulate sorting and trafficking into multivesicular bodies en route to the lysosome. The physical mechanism responsible for generating lumenal vesicles in this pathway is unknown. Here we review recent studies suggesting that components of the ESCRT-III complex drive lumenal vesicle formation and consider possible mechanisms for this reaction.",

author = "Hanson, {Phyllis I.} and Soomin Shim and Merrill, {Samuel A.}",

note = "Funding Information: We thank John Heuser and Robyn Roth for their collaboration, insight, and discussion in our studies of the ESCRT machinery. Work on the ESCRT machinery in the Hanson laboratory is supported by grants from the NIH (R01 GM076686) and the American Heart Association.",

year = "2009",

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doi = "10.1016/j.ceb.2009.06.002",

language = "English (US)",

volume = "21",

pages = "568--574",

journal = "Current Opinion in Cell Biology",

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T1 - Cell biology of the ESCRT machinery

AU - Hanson, Phyllis I.

AU - Shim, Soomin

AU - Merrill, Samuel A.

N1 - Funding Information: We thank John Heuser and Robyn Roth for their collaboration, insight, and discussion in our studies of the ESCRT machinery. Work on the ESCRT machinery in the Hanson laboratory is supported by grants from the NIH (R01 GM076686) and the American Heart Association.

PY - 2009/8

Y1 - 2009/8

N2 - The ESCRT (endosomal sorting complex required for transport) machinery comprises a set of protein complexes that regulate sorting and trafficking into multivesicular bodies en route to the lysosome. The physical mechanism responsible for generating lumenal vesicles in this pathway is unknown. Here we review recent studies suggesting that components of the ESCRT-III complex drive lumenal vesicle formation and consider possible mechanisms for this reaction.

AB - The ESCRT (endosomal sorting complex required for transport) machinery comprises a set of protein complexes that regulate sorting and trafficking into multivesicular bodies en route to the lysosome. The physical mechanism responsible for generating lumenal vesicles in this pathway is unknown. Here we review recent studies suggesting that components of the ESCRT-III complex drive lumenal vesicle formation and consider possible mechanisms for this reaction.

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U2 - 10.1016/j.ceb.2009.06.002

DO - 10.1016/j.ceb.2009.06.002

M3 - Review article

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AN - SCOPUS:67949114331

SN - 0955-0674

VL - 21

SP - 568

EP - 574

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 4

ER -

Cell biology of the ESCRT machinery

Abstract

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