Cell-based measurements of mitochondrial function in human subjects

Ju Gyeong Kang, Ping Yuan Wang, Paul M. Hwang

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

There is growing evidence in the basic science field that aberrant metabolism plays an important role in tumorigenesis. Therefore, it is imperative to perform investigations in human subjects to determine (1) whether the metabolic observations made in model systems are applicable to humans; and (2) if indeed applicable, whether the metabolic alterations are clinically significant for cancer development. As an initial step, here we describe methods for measuring the mitochondrial metabolism of blood lymphocytes and skeletal muscle myoblasts that can be obtained from human subjects.

Original languageEnglish (US)
Title of host publicationConceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism
PublisherAcademic Press Inc.
Pages209-221
Number of pages13
ISBN (Print)9780124166189
DOIs
StatePublished - 2014

Publication series

NameMethods in Enzymology
Volume542
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Keywords

  • Human
  • Lymphocytes
  • Mitochondria
  • Myoblasts
  • Respiration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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