Cell adhesion molecules in normal laryngeal development

A. M.S. Soliman, R. M. Jones, P. W. Flint

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Larynges taken from normally developing rats ranging from embryos starting at embryonic day 10 to adults were harvested. Sections of the larynges were prepared with the use of immunohistochemical techniques with primary antibodies directed to the neural cell adhesion molecule; selected sections were exposed to antibodies directed against the embryonic polysialated form of the neural cell adhesion molecule and against L1. Cell adhesion molecules were present throughout embryonic development associated with the recurrent laryngeal nerve. Downregulation of expression was observed after postnatal day 14. We conclude that cell adhesion molecules may play a role in the normal neural development of the larynx in rats.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalOtolaryngology - Head and Neck Surgery
Issue number1
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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