Cell adhesion and chemotaxis in prostate cancer metastasis to bone: A minireview

C. R. Cooper, K. J. Pienta

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Bone metastasis is a common phenomenon in patients with advanced prostate cancer. The molecular and cellular mechanisms involved in this process are not well understood. Past reviews on this subject primarily focused on prostate tumor growth in the bone marrow and the effects this growth has on bone homeostasis (ie osteoblastic and osteolytic). Cell chemotaxis and adhesion are also important for site-specific metastasis. In this review we have focused on chemotactic and cell adhesion molecules potentially involved in prostate cancer metastasis to bone. In addition, recently developed animal models for prostate cancer metastasis to bone are discussed.

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalProstate Cancer and Prostatic Diseases
Issue number1
StatePublished - 2000
Externally publishedYes


  • Cell adhesion molecules
  • Chemoattractants
  • Cytokines
  • Human bone marrow endothelial cells
  • Prostate cancer cells

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research


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