Abstract
Bone metastasis is a common phenomenon in patients with advanced prostate cancer. The molecular and cellular mechanisms involved in this process are not well understood. Past reviews on this subject primarily focused on prostate tumor growth in the bone marrow and the effects this growth has on bone homeostasis (ie osteoblastic and osteolytic). Cell chemotaxis and adhesion are also important for site-specific metastasis. In this review we have focused on chemotactic and cell adhesion molecules potentially involved in prostate cancer metastasis to bone. In addition, recently developed animal models for prostate cancer metastasis to bone are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6-12 |
| Number of pages | 7 |
| Journal | Prostate Cancer and Prostatic Diseases |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2000 |
| Externally published | Yes |
Keywords
- Cell adhesion molecules
- Chemoattractants
- Cytokines
- Human bone marrow endothelial cells
- Prostate cancer cells
ASJC Scopus subject areas
- Oncology
- Urology
- Cancer Research