TY - JOUR
T1 - Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages
AU - Scheel, Olaf
AU - Papavlassopoulos, Martin
AU - Blunck, Rikard
AU - Gebert, Andreas
AU - Hartung, Thomas
AU - Zähringer, Ulrich
AU - Seydel, Ulrich
AU - Schromm, Andra B.
PY - 2006/7
Y1 - 2006/7
N2 - Performing patch-clamp experiments on human macrophages, we show that the K+ channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for functional association of the MaxiK channel and TLR signaling complexes.
AB - Performing patch-clamp experiments on human macrophages, we show that the K+ channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for functional association of the MaxiK channel and TLR signaling complexes.
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U2 - 10.1128/IAI.01783-05
DO - 10.1128/IAI.01783-05
M3 - Article
C2 - 16790810
AN - SCOPUS:33745608998
SN - 0019-9567
VL - 74
SP - 4354
EP - 4356
JO - Infection and immunity
JF - Infection and immunity
IS - 7
ER -