CDK12 deficiency and the immune microenvironment in prostate cancer

Tamara L. Lotan; Emmanuel S. Antonarakis

doi:10.1158/1078-0432.CCR-20-3877

CDK12 deficiency and the immune microenvironment in prostate cancer

Tamara L. Lotan
, Emmanuel S. Antonarakis

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

CDK12 inactivation in prostate cancer is associated with tandem genomic duplications that may generate fusion-associated neoantigens and elicit immune responses amenable to checkpoint blockade. In the first study to comprehensively characterize the T-cell immune microenvironment of CDK12-deficient prostate cancers, subsets of immunosuppressive CD4^þFOXP3 T cells were increased compared with CDK12-proficient controls.

Original language	English (US)
Pages (from-to)	380-382
Number of pages	3
Journal	Clinical Cancer Research
Volume	27
Issue number	2
DOIs	https://doi.org/10.1158/1078-0432.CCR-20-3877
State	Published - Jan 15 2021

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/1078-0432.CCR-20-3877

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title = "CDK12 deficiency and the immune microenvironment in prostate cancer",

abstract = "CDK12 inactivation in prostate cancer is associated with tandem genomic duplications that may generate fusion-associated neoantigens and elicit immune responses amenable to checkpoint blockade. In the first study to comprehensively characterize the T-cell immune microenvironment of CDK12-deficient prostate cancers, subsets of immunosuppressive CD4{\th}FOXP3 T cells were increased compared with CDK12-proficient controls.",

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AB - CDK12 inactivation in prostate cancer is associated with tandem genomic duplications that may generate fusion-associated neoantigens and elicit immune responses amenable to checkpoint blockade. In the first study to comprehensively characterize the T-cell immune microenvironment of CDK12-deficient prostate cancers, subsets of immunosuppressive CD4þFOXP3 T cells were increased compared with CDK12-proficient controls.

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CDK12 deficiency and the immune microenvironment in prostate cancer

Abstract

ASJC Scopus subject areas

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