CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence

Scott M. Krummey; Anna B. Morris; Jesica R. Jacobs; Donald J. McGuire; Satomi Ando; Katherine P. Tong; Weiwen Zhang; Jennifer Robertson; Sara A. Guasch; Koichi Araki; Christian P. Larsen; Brian D. Evavold; Haydn T. Kissick; Mandy L. Ford

doi:10.1016/j.celrep.2020.01.016

CD45RB Status of CD8⁺ T Cell Memory Defines T Cell Receptor Affinity and Persistence

Scott M. Krummey, Anna B. Morris, Jesica R. Jacobs, Donald J. McGuire, Satomi Ando, Katherine P. Tong, Weiwen Zhang, Jennifer Robertson, Sara A. Guasch, Koichi Araki, Christian P. Larsen, Brian D. Evavold, Haydn T. Kissick, Mandy L. Ford

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Krummey et al. show that viral CD8⁺ T cell memory has heterogeneous CD45 isoform expression. Low-affinity CD8⁺ T cells have high CD45RB expression and a CD27^hiCD62L^hi phenotype relative to high-affinity CD45RB^lo CD8⁺ T cells, which possess an effector-like phenotype. CD45RB^hi cells survive better under homeostatic conditions in vivo.

Original language	English (US)
Pages (from-to)	1282-1291.e5
Journal	Cell Reports
Volume	30
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2020.01.016
State	Published - Feb 4 2020
Externally published	Yes

Keywords

CD45
T cell memory
TCR affinity

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2020.01.016

Cite this

Krummey, S. M., Morris, A. B., Jacobs, J. R., McGuire, D. J., Ando, S., Tong, K. P., Zhang, W., Robertson, J., Guasch, S. A., Araki, K., Larsen, C. P., Evavold, B. D., Kissick, H. T., & Ford, M. L. (2020). CD45RB Status of CD8⁺ T Cell Memory Defines T Cell Receptor Affinity and Persistence. Cell Reports, 30(5), 1282-1291.e5. https://doi.org/10.1016/j.celrep.2020.01.016

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abstract = "Krummey et al. show that viral CD8+ T cell memory has heterogeneous CD45 isoform expression. Low-affinity CD8+ T cells have high CD45RB expression and a CD27hiCD62Lhi phenotype relative to high-affinity CD45RBlo CD8+ T cells, which possess an effector-like phenotype. CD45RBhi cells survive better under homeostatic conditions in vivo.",

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AU - Krummey, Scott M.

AU - Morris, Anna B.

AU - Jacobs, Jesica R.

AU - McGuire, Donald J.

AU - Ando, Satomi

AU - Tong, Katherine P.

AU - Zhang, Weiwen

AU - Robertson, Jennifer

AU - Guasch, Sara A.

AU - Araki, Koichi

AU - Larsen, Christian P.

AU - Evavold, Brian D.

AU - Kissick, Haydn T.

AU - Ford, Mandy L.

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AB - Krummey et al. show that viral CD8+ T cell memory has heterogeneous CD45 isoform expression. Low-affinity CD8+ T cells have high CD45RB expression and a CD27hiCD62Lhi phenotype relative to high-affinity CD45RBlo CD8+ T cells, which possess an effector-like phenotype. CD45RBhi cells survive better under homeostatic conditions in vivo.

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KW - T cell memory

KW - TCR affinity

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