@article{9f8c581f6c9e435ebec0b4d3a5d3566e,
title = "CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence",
abstract = "Krummey et al. show that viral CD8+ T cell memory has heterogeneous CD45 isoform expression. Low-affinity CD8+ T cells have high CD45RB expression and a CD27hiCD62Lhi phenotype relative to high-affinity CD45RBlo CD8+ T cells, which possess an effector-like phenotype. CD45RBhi cells survive better under homeostatic conditions in vivo.",
keywords = "CD45, T cell memory, TCR affinity",
author = "Krummey, {Scott M.} and Morris, {Anna B.} and Jacobs, {Jesica R.} and McGuire, {Donald J.} and Satomi Ando and Tong, {Katherine P.} and Weiwen Zhang and Jennifer Robertson and Guasch, {Sara A.} and Koichi Araki and Larsen, {Christian P.} and Evavold, {Brian D.} and Kissick, {Haydn T.} and Ford, {Mandy L.}",
note = "Funding Information: The authors would like to thank the Emory+Children{\textquoteright}s Flow Cytometry Core and the Emory Flow Cytometry Core for FACS sorting, the Yerkes Genomics Core for sequencing services and support, and the NIH Tetramer Core for tetramer production. This work was supported by NIAID/NIH awards AI104699 , AI070307 (M.L.F.), and K99 AI146271 (S.M.K.) and funding from the James M. Cox Foundation (C.P.L.) and the Carlos and Marguerite Mason Trust (C.P.L.). The authors also thank members of the Emory Transplant Center and Matthew Z. Madden for helpful discussions. Experimental schematics were created with Biorender.com . Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = feb,
day = "4",
doi = "10.1016/j.celrep.2020.01.016",
language = "English (US)",
volume = "30",
pages = "1282--1291.e5",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "5",
}