CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation

A. G M Stam; S. J A M Santegoets; T. M. Westers; C. C. Sombroek; J. J W M Janssen; B. W. Tillman; A. A. Van De Loosdrecht; H. M. Pinedo; D. T. Curiel; G. J. Ossenkoppele; R. J. Scheper; T. D. De Gruijl

doi:10.1038/sj.bjc.6601225

CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation

A. G M Stam, S. J A M Santegoets, T. M. Westers, C. C. Sombroek, J. J W M Janssen, B. W. Tillman, A. A. Van De Loosdrecht, H. M. Pinedo, D. T. Curiel, G. J. Ossenkoppele, R. J. Scheper, T. D. De Gruijl

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.

Original language	English (US)
Pages (from-to)	1162-1165
Number of pages	4
Journal	British Journal of Cancer
Volume	89
Issue number	7
DOIs	https://doi.org/10.1038/sj.bjc.6601225
State	Published - Oct 6 2003
Externally published	Yes

Keywords

Adenovirus
CD40 ligation
CML
Dendritic cell
GM-CSF
Immunotherapy

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1038/sj.bjc.6601225

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Stam, A. G. M., Santegoets, S. J. A. M., Westers, T. M., Sombroek, C. C., Janssen, J. J. W. M., Tillman, B. W., Van De Loosdrecht, A. A., Pinedo, H. M., Curiel, D. T., Ossenkoppele, G. J., Scheper, R. J., & De Gruijl, T. D. (2003). CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation. British Journal of Cancer, 89(7), 1162-1165. https://doi.org/10.1038/sj.bjc.6601225

Stam, AGM, Santegoets, SJAM, Westers, TM, Sombroek, CC, Janssen, JJWM, Tillman, BW, Van De Loosdrecht, AA, Pinedo, HM, Curiel, DT, Ossenkoppele, GJ, Scheper, RJ & De Gruijl, TD 2003, 'CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation', British Journal of Cancer, vol. 89, no. 7, pp. 1162-1165. https://doi.org/10.1038/sj.bjc.6601225

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abstract = "Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.",

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AU - Santegoets, S. J A M

AU - Westers, T. M.

AU - Sombroek, C. C.

AU - Janssen, J. J W M

AU - Tillman, B. W.

AU - Van De Loosdrecht, A. A.

AU - Pinedo, H. M.

AU - Curiel, D. T.

AU - Ossenkoppele, G. J.

AU - Scheper, R. J.

AU - De Gruijl, T. D.

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CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation

Abstract

Keywords

ASJC Scopus subject areas

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