CBCRisk-Black: a personalized contralateral breast cancer risk prediction model for black women

Ibrahim Hossain Sajal, Marzana Chowdhury, Tingfang Wang, David Euhus, Pankaj K. Choudhary, Swati Biswas

Research output: Contribution to journalArticlepeer-review


Purpose: Black breast cancer (BC) survivors have a higher risk of developing contralateral breast cancer (CBC) than Whites. Existing CBC risk prediction tools are developed based on mostly White women. To address this racial disparity, it is crucial to develop tools tailored for Black women to help them inform about their actual risk of CBC. Methods: We propose an absolute risk prediction model, CBCRisk-Black, specifically for Black BC patients. It uses data on Black women from two sources: Breast Cancer Surveillance Consortium (BCSC) and Surveillance, Epidemiology, and End Results (SEER). First, a matched lasso logistic regression model for estimating relative risks (RR) is developed. Then, it is combined with relevant hazard rates and attributable risks to obtain absolute risks. Six-fold cross-validation is used to internally validate CBCRisk-Black. We also compare CBCRisk-Black with CBCRisk, an existing CBC risk prediction model. Results: The RR model uses data from BCSC on 744 Black women (186 cases). CBCRisk-Black has four risk factors (RR compared to baseline): breast density (2.13 for heterogeneous/extremely dense), family history of BC (2.28 for yes), first BC tumor size (2.14 for T3/T4, 1.56 for TIS), and age at first diagnosis of BC (1.41 for < 40). The area under the receiver operating characteristic curve (AUC) for 3- and 5-year predictions are 0.72 and 0.65 for CBCRisk-Black while those are 0.65 and 0.60 for CBCRisk. Conclusion: CBCRisk-Black may serve as a useful tool to clinicians in counseling Black BC patients by providing a more accurate and personalized CBC risk estimate.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalBreast Cancer Research and Treatment
Issue number1
StatePublished - Jul 2022


  • BCSC
  • Black
  • CBCRisk
  • Contralateral breast cancer
  • Lasso
  • Racial disparity
  • Risk prediction

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'CBCRisk-Black: a personalized contralateral breast cancer risk prediction model for black women'. Together they form a unique fingerprint.

Cite this