Causality of mesothelioma: SV40 question

Keerti V. Shah

doi:10.1016/S1547-4127(04)00112-4

Causality of mesothelioma: SV40 question

Keerti V. Shah

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The reported link between SV40 and mesothelioma is questionable. The most recent studies do not confirm the previous reports of SV40 sequences in mesothelioma tissues, and one study raises the possibility that contamination with common laboratory plasmids may account for some of the previous data. Individuals exposed to SV40 in contaminated vaccines have not been shown to be at increased risk for mesothelioma. With SV40 and mesothelioma, the data on viral sequences in tumors are inconsistent and disputed, and serologic evidence does not support any association. The epidemiologic data do not show that documented exposures to SV40 increase the risk of mesothelioma. It seems unlikely that infection with SV40 contributes to the development of human mesothelioma or of any other human cancer.

Original language	English (US)
Pages (from-to)	497-504
Number of pages	8
Journal	Thoracic surgery clinics
Volume	14
Issue number	4 SPEC. ISS.
DOIs	https://doi.org/10.1016/S1547-4127(04)00112-4
State	Published - Nov 2004
Externally published	Yes

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine

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10.1016/S1547-4127(04)00112-4

Cite this

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title = "Causality of mesothelioma: SV40 question",

abstract = "The reported link between SV40 and mesothelioma is questionable. The most recent studies do not confirm the previous reports of SV40 sequences in mesothelioma tissues, and one study raises the possibility that contamination with common laboratory plasmids may account for some of the previous data. Individuals exposed to SV40 in contaminated vaccines have not been shown to be at increased risk for mesothelioma. With SV40 and mesothelioma, the data on viral sequences in tumors are inconsistent and disputed, and serologic evidence does not support any association. The epidemiologic data do not show that documented exposures to SV40 increase the risk of mesothelioma. It seems unlikely that infection with SV40 contributes to the development of human mesothelioma or of any other human cancer.",

author = "Shah, {Keerti V.}",

note = "Funding Information: This article was supported in part by Cancer Research Grant F402 from the Maryland Cigarette Restitution Fund. ",

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AU - Shah, Keerti V.

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PY - 2004/11

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N2 - The reported link between SV40 and mesothelioma is questionable. The most recent studies do not confirm the previous reports of SV40 sequences in mesothelioma tissues, and one study raises the possibility that contamination with common laboratory plasmids may account for some of the previous data. Individuals exposed to SV40 in contaminated vaccines have not been shown to be at increased risk for mesothelioma. With SV40 and mesothelioma, the data on viral sequences in tumors are inconsistent and disputed, and serologic evidence does not support any association. The epidemiologic data do not show that documented exposures to SV40 increase the risk of mesothelioma. It seems unlikely that infection with SV40 contributes to the development of human mesothelioma or of any other human cancer.

AB - The reported link between SV40 and mesothelioma is questionable. The most recent studies do not confirm the previous reports of SV40 sequences in mesothelioma tissues, and one study raises the possibility that contamination with common laboratory plasmids may account for some of the previous data. Individuals exposed to SV40 in contaminated vaccines have not been shown to be at increased risk for mesothelioma. With SV40 and mesothelioma, the data on viral sequences in tumors are inconsistent and disputed, and serologic evidence does not support any association. The epidemiologic data do not show that documented exposures to SV40 increase the risk of mesothelioma. It seems unlikely that infection with SV40 contributes to the development of human mesothelioma or of any other human cancer.

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Causality of mesothelioma: SV40 question

Abstract

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