Causality of mesothelioma: SV40 question

Keerti V. Shah

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


The reported link between SV40 and mesothelioma is questionable. The most recent studies do not confirm the previous reports of SV40 sequences in mesothelioma tissues, and one study raises the possibility that contamination with common laboratory plasmids may account for some of the previous data. Individuals exposed to SV40 in contaminated vaccines have not been shown to be at increased risk for mesothelioma. With SV40 and mesothelioma, the data on viral sequences in tumors are inconsistent and disputed, and serologic evidence does not support any association. The epidemiologic data do not show that documented exposures to SV40 increase the risk of mesothelioma. It seems unlikely that infection with SV40 contributes to the development of human mesothelioma or of any other human cancer.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalThoracic surgery clinics
Issue number4 SPEC. ISS.
StatePublished - Nov 2004
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine


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