Caught in the act: α-synuclein is the culprit in Parkinson's disease

Jason L. Eriksen, Ted M. Dawson, Dennis W. Dickson, Leonard Petrucelli

Research output: Contribution to journalReview articlepeer-review

132 Scopus citations


Previous reports on Parkinson's disease indicate that genetic mutations in α-synuclein result in the aberrant accumulation of this protein, causing toxic gain of function leading to the development of Parkinson's. A recent report on the Iowan kindred, an extended pedigree with an autosomal dominant form of this disease, provides new mechanistic insight into Parkinson's disease by showing that an elevation in wild-type α-synuclein protein is sufficient to develop the early-onset form of the disorder. This review discusses how insights gained from these studies of α-synuclein may direct future research into Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)453-456
Number of pages4
Issue number3
StatePublished - Oct 30 2003

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Caught in the act: α-synuclein is the culprit in Parkinson's disease'. Together they form a unique fingerprint.

Cite this