Caudal hindbrain neuromedin B-preferring receptors participate in the control of food intake

E. E. Ladenheim; J. E. Taylor; D. H. Coy; T. S. Carrigan; A. Wohn; T. H. Moran

doi:10.1152/ajpregu.1997.272.1.r433

Caudal hindbrain neuromedin B-preferring receptors participate in the control of food intake

E. E. Ladenheim, J. E. Taylor, D. H. Coy, T. S. Carrigan, A. Wohn, T. H. Moran

School of Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Recent studies have identified two subtypes of bombesin (BN) receptors in the rat central nervous system: gastrin releasing-peptide (GRP) preferring and neuromedin B (NMB) preferring. To investigate a role for the NMB- preferring receptor subtype in feeding suppression elicited by fourth ventricular (4V) BN administration, we evaluated the ability of a selective NMB-preferring receptor antagonist, BIM-23127, to block suppression of glucose intake produced by 4V BN (10 pmol). Our results showed that 4V administration of BIM-23127 dose dependently antagonized the suppression of glucose intake produced by 4V BN. In addition, 4V administration of BIM- 23127 alone increased glucose intake above that observed in the baseline condition. These results support a role for the NMB-preferring BN receptor subtype in the suppression of intake produced by 4V BN administration and suggest that endogenously released NMB participates in ingestive control.

Original language	English (US)
Pages (from-to)	R433-R437
Journal	American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume	272
Issue number	1 41-1
DOIs	https://doi.org/10.1152/ajpregu.1997.272.1.r433
State	Published - 1997

Keywords

bombesin
caudal brain stem

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.1152/ajpregu.1997.272.1.r433

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title = "Caudal hindbrain neuromedin B-preferring receptors participate in the control of food intake",

abstract = "Recent studies have identified two subtypes of bombesin (BN) receptors in the rat central nervous system: gastrin releasing-peptide (GRP) preferring and neuromedin B (NMB) preferring. To investigate a role for the NMB- preferring receptor subtype in feeding suppression elicited by fourth ventricular (4V) BN administration, we evaluated the ability of a selective NMB-preferring receptor antagonist, BIM-23127, to block suppression of glucose intake produced by 4V BN (10 pmol). Our results showed that 4V administration of BIM-23127 dose dependently antagonized the suppression of glucose intake produced by 4V BN. In addition, 4V administration of BIM- 23127 alone increased glucose intake above that observed in the baseline condition. These results support a role for the NMB-preferring BN receptor subtype in the suppression of intake produced by 4V BN administration and suggest that endogenously released NMB participates in ingestive control.",

keywords = "bombesin, caudal brain stem",

author = "Ladenheim, {E. E.} and Taylor, {J. E.} and Coy, {D. H.} and Carrigan, {T. S.} and A. Wohn and Moran, {T. H.}",

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doi = "10.1152/ajpregu.1997.272.1.r433",

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AU - Ladenheim, E. E.

AU - Taylor, J. E.

AU - Coy, D. H.

AU - Carrigan, T. S.

AU - Wohn, A.

AU - Moran, T. H.

PY - 1997

Y1 - 1997

N2 - Recent studies have identified two subtypes of bombesin (BN) receptors in the rat central nervous system: gastrin releasing-peptide (GRP) preferring and neuromedin B (NMB) preferring. To investigate a role for the NMB- preferring receptor subtype in feeding suppression elicited by fourth ventricular (4V) BN administration, we evaluated the ability of a selective NMB-preferring receptor antagonist, BIM-23127, to block suppression of glucose intake produced by 4V BN (10 pmol). Our results showed that 4V administration of BIM-23127 dose dependently antagonized the suppression of glucose intake produced by 4V BN. In addition, 4V administration of BIM- 23127 alone increased glucose intake above that observed in the baseline condition. These results support a role for the NMB-preferring BN receptor subtype in the suppression of intake produced by 4V BN administration and suggest that endogenously released NMB participates in ingestive control.

AB - Recent studies have identified two subtypes of bombesin (BN) receptors in the rat central nervous system: gastrin releasing-peptide (GRP) preferring and neuromedin B (NMB) preferring. To investigate a role for the NMB- preferring receptor subtype in feeding suppression elicited by fourth ventricular (4V) BN administration, we evaluated the ability of a selective NMB-preferring receptor antagonist, BIM-23127, to block suppression of glucose intake produced by 4V BN (10 pmol). Our results showed that 4V administration of BIM-23127 dose dependently antagonized the suppression of glucose intake produced by 4V BN. In addition, 4V administration of BIM- 23127 alone increased glucose intake above that observed in the baseline condition. These results support a role for the NMB-preferring BN receptor subtype in the suppression of intake produced by 4V BN administration and suggest that endogenously released NMB participates in ingestive control.

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ER -

Caudal hindbrain neuromedin B-preferring receptors participate in the control of food intake

Abstract

Keywords

ASJC Scopus subject areas

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