Abstract
Background - We tested the feasibility of targeted left ventricular (LV) mural injection using real-time MRI (rtMRI). Methods and Results - A 1.5T MRI scanner was customized with a fast reconstruction engine, transfemoral guiding catheter-receiver coil (GCC), MRI-compatible needle, and tableside consoles. Commercial real-time imaging software was customized to facilitate catheter navigation and visualization of injections at 4 completely refreshed frames per second. The aorta was traversed and the left ventricular cavity was entered under direct rtMRI guidance. Pigs underwent multiple injections with dilute gadolinium-DTPA. All myocardial segments were readily accessed. The active GCC and the passive Stiletto needle injector were readily visualized. More than 50 endomyocardial injections were performed with the aid of rtMRI; 81% were successful with this first-generation prototype. Conclusion - Percutaneous endomyocardial drug delivery is feasible with the aid of rtMRI, which permits precise 3-dimensional localization of injection within the LV wall.
Original language | English (US) |
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Pages (from-to) | 1282-1284 |
Number of pages | 3 |
Journal | Circulation |
Volume | 105 |
Issue number | 11 |
DOIs | |
State | Published - Mar 19 2002 |
Externally published | Yes |
Keywords
- Catheterization
- Drugs
- Ischemia
- Magnetic resonance imaging
- Radiography
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)