Abstract
The antibiofilm activities of caspofungin, anidulafungin, micafungin, and liposomal amphotericin B were studied against Candida lusitaniae, Candida guilliermondii, and a Candida albicans control strain. While anidulafungin and micafungin (0.007 to 2,048 mg/liter) showed reduced activity against biofilms of both test species, caspofungin displayed concentration-dependent antibiofilm activity, reaching complete and persistent eradication at concentrations achievable during lock therapy (512 to 2,048 mg/liter, P<0.05). Although liposomal amphotericin B strongly inhibited mature biofilms, it possessed lower antibiofilm activity than caspofungin (P<0.05).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4953-4956 |
| Number of pages | 4 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 58 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2014 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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