Casein Production by Human Breast Cancer

Marie E. Monaco, Diane A. Bronzed, Douglass C. Tormey, Phillip Waalkes, Marc E. Lippman

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Casein was measured in the sera of breast cancer patients, in breast cancer tumors, and in breast cancer cells in long-term tissue culture using a sensitive and specific radioimmunoassay. Levels present in breast cancer sera were not elevated above control values. Eight of forty-seven (17%) of the tumor samples tested were positive for casein, the highest level representing 0.003% of the soluble protein. When seven human breast cancer cell lines were assayed for casein, the results were uniformly negative even under conditions of stimulation by lactogenic hormones. In addition, direct immunoprecipitation of labeled cellular protein supported the negative result of the radioimmunoassay. Thus it appears that casein production is not a common characteristic of most human breast cancers.

Original languageEnglish (US)
Pages (from-to)749-754
Number of pages6
JournalCancer Research
Issue number3
StatePublished - Mar 1977

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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