Case study and review: Treatment of tricuspid prosthetic valve thrombosis

David Yi Zhang; Jay Lozier; Richard Chang; Vandana Sachdev; Marcus Y. Chen; Jennifer L. Audibert; Keith A. Horvath; Douglas R. Rosing

doi:10.1016/j.ijcard.2011.09.081

Case study and review: Treatment of tricuspid prosthetic valve thrombosis

David Yi Zhang, Jay Lozier, Richard Chang, Vandana Sachdev, Marcus Y. Chen, Jennifer L. Audibert, Keith A. Horvath, Douglas R. Rosing

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Prosthetic valve thrombosis (PVT) is a severe and life-threatening complication of heart valve replacement. Conventional therapy is surgical thrombectomy or valve replacement. Medical thrombolysis is another emerging option. We report the case of a 57 year old woman with a history of Ebstein anomaly who underwent successful treatment of tricuspid prosthetic valve thrombosis with intra-atrial infusion of very low dose recombinant tissue plasminogen activator (tPA). We review the presentation, etiology, diagnosis, and treatment of tricuspid PVT emphasizing a modified medical option as a safe, minimally invasive alternative to surgical intervention or conventional medical therapy for tricuspid valve thrombosis.

Original language	English (US)
Pages (from-to)	14-19
Number of pages	6
Journal	International Journal of Cardiology
Volume	162
Issue number	1
DOIs	https://doi.org/10.1016/j.ijcard.2011.09.081
State	Published - Dec 15 2012
Externally published	Yes

Keywords

Ebstein anomaly
Pannus
Prosthetic valve
Recombinant tissue plasminogen activator (tPa)
Thrombosis, thrombolysis, fibrinolysis
Tricuspid valve

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ijcard.2011.09.081

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title = "Case study and review: Treatment of tricuspid prosthetic valve thrombosis",

abstract = "Prosthetic valve thrombosis (PVT) is a severe and life-threatening complication of heart valve replacement. Conventional therapy is surgical thrombectomy or valve replacement. Medical thrombolysis is another emerging option. We report the case of a 57 year old woman with a history of Ebstein anomaly who underwent successful treatment of tricuspid prosthetic valve thrombosis with intra-atrial infusion of very low dose recombinant tissue plasminogen activator (tPA). We review the presentation, etiology, diagnosis, and treatment of tricuspid PVT emphasizing a modified medical option as a safe, minimally invasive alternative to surgical intervention or conventional medical therapy for tricuspid valve thrombosis.",

keywords = "Ebstein anomaly, Pannus, Prosthetic valve, Recombinant tissue plasminogen activator (tPa), Thrombosis, thrombolysis, fibrinolysis, Tricuspid valve",

author = "Zhang, {David Yi} and Jay Lozier and Richard Chang and Vandana Sachdev and Chen, {Marcus Y.} and Audibert, {Jennifer L.} and Horvath, {Keith A.} and Rosing, {Douglas R.}",

note = "Funding Information: Supported by the Intramural Research Programs of the National Heart, Lung, and Blood Institute (NHLBI) and Clinical Center (CC) of the National Institutes of Health . ",

year = "2012",

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day = "15",

doi = "10.1016/j.ijcard.2011.09.081",

language = "English (US)",

volume = "162",

pages = "14--19",

journal = "International Journal of Cardiology",

issn = "0167-5273",

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T2 - Treatment of tricuspid prosthetic valve thrombosis

AU - Zhang, David Yi

AU - Lozier, Jay

AU - Chang, Richard

AU - Sachdev, Vandana

AU - Chen, Marcus Y.

AU - Audibert, Jennifer L.

AU - Horvath, Keith A.

AU - Rosing, Douglas R.

N1 - Funding Information: Supported by the Intramural Research Programs of the National Heart, Lung, and Blood Institute (NHLBI) and Clinical Center (CC) of the National Institutes of Health .

PY - 2012/12/15

Y1 - 2012/12/15

N2 - Prosthetic valve thrombosis (PVT) is a severe and life-threatening complication of heart valve replacement. Conventional therapy is surgical thrombectomy or valve replacement. Medical thrombolysis is another emerging option. We report the case of a 57 year old woman with a history of Ebstein anomaly who underwent successful treatment of tricuspid prosthetic valve thrombosis with intra-atrial infusion of very low dose recombinant tissue plasminogen activator (tPA). We review the presentation, etiology, diagnosis, and treatment of tricuspid PVT emphasizing a modified medical option as a safe, minimally invasive alternative to surgical intervention or conventional medical therapy for tricuspid valve thrombosis.

AB - Prosthetic valve thrombosis (PVT) is a severe and life-threatening complication of heart valve replacement. Conventional therapy is surgical thrombectomy or valve replacement. Medical thrombolysis is another emerging option. We report the case of a 57 year old woman with a history of Ebstein anomaly who underwent successful treatment of tricuspid prosthetic valve thrombosis with intra-atrial infusion of very low dose recombinant tissue plasminogen activator (tPA). We review the presentation, etiology, diagnosis, and treatment of tricuspid PVT emphasizing a modified medical option as a safe, minimally invasive alternative to surgical intervention or conventional medical therapy for tricuspid valve thrombosis.

KW - Ebstein anomaly

KW - Pannus

KW - Prosthetic valve

KW - Recombinant tissue plasminogen activator (tPa)

KW - Thrombosis, thrombolysis, fibrinolysis

KW - Tricuspid valve

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U2 - 10.1016/j.ijcard.2011.09.081

DO - 10.1016/j.ijcard.2011.09.081

M3 - Review article

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AN - SCOPUS:84870241080

SN - 0167-5273

VL - 162

SP - 14

EP - 19

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 1

ER -

Case study and review: Treatment of tricuspid prosthetic valve thrombosis

Abstract

Keywords

ASJC Scopus subject areas

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