Case study and review: Treatment of tricuspid prosthetic valve thrombosis

David Yi Zhang, Jay Lozier, Richard Chang, Vandana Sachdev, Marcus Y. Chen, Jennifer L. Audibert, Keith A. Horvath, Douglas R. Rosing

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Prosthetic valve thrombosis (PVT) is a severe and life-threatening complication of heart valve replacement. Conventional therapy is surgical thrombectomy or valve replacement. Medical thrombolysis is another emerging option. We report the case of a 57 year old woman with a history of Ebstein anomaly who underwent successful treatment of tricuspid prosthetic valve thrombosis with intra-atrial infusion of very low dose recombinant tissue plasminogen activator (tPA). We review the presentation, etiology, diagnosis, and treatment of tricuspid PVT emphasizing a modified medical option as a safe, minimally invasive alternative to surgical intervention or conventional medical therapy for tricuspid valve thrombosis.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalInternational Journal of Cardiology
Issue number1
StatePublished - Dec 15 2012
Externally publishedYes


  • Ebstein anomaly
  • Pannus
  • Prosthetic valve
  • Recombinant tissue plasminogen activator (tPa)
  • Thrombosis, thrombolysis, fibrinolysis
  • Tricuspid valve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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