Abstract
With impending rollout of new conjugate typhoid vaccines, better estimates of typhoid case-fatality ratio are needed for countries to set priorities for public health programs. We enrolled 1425 patients of all ages with blood culture-confirmed Salmonella Typhi from laboratory networks serving inpatients and outpatients in Dhaka, Bangladesh. Participants were asked about symptoms and complications including death experienced over a median 3-month period following blood culture diagnosis. Four fatal cases were identified (case-fatality ratio of 0.3% [95% confidence interval,.05%-.55%]). Applying this case-fatality ratio to global typhoid burden estimates would reduce deaths by 70%.
Original language | English (US) |
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Pages (from-to) | S222-S226 |
Journal | Journal of Infectious Diseases |
Volume | 218 |
DOIs | |
State | Published - Nov 10 2018 |
Keywords
- case-fatality ratio
- enteric fever
- global burden of disease
- laboratory-based surveillance
- typhoid
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases