TY - JOUR
T1 - Case-control study of endemic diarrheal disease in thai children
AU - Echeverria, Peter
AU - Taylor, David N.
AU - Lexsomboon, Udom
AU - Bhaibulaya, Manoon
AU - Blacklow, Neil R.
AU - Tamura, Kazumichi
AU - Sakazaki, Riichi
N1 - Funding Information:
Received for publication 23 May 1988 and in revised form 13 September 1988. This study was supported by grant 84215 from the Diarrheal Disease Research Programme of the World Health Organization and the u.s. Army Research and Development Command. Wethank Drs. K. A. Bettelheim (Fairfield Hospital, Melbourne, Australia) and F.and l. Orskov (World Health Organization Escherichia and Klebsiella Reference Center, Copenhagen, Denmark) for serotyping E. coli isolates; Aroon Bangtrakulnonth (Department of Medical Science, Thai Ministry of Health) for serotyping the Salmonella isolates; the technicians and nurses of the Department of Bacteriology at the Armed Forces Research Institute of Medical Sciences for their excellent technical assistance; and N. Siripraivan for preparing the manuscript. Please address requests for reprints to Dr. Peter Echeverria, Armed Forces Research Institute of Medical Sciences, APO San Francisco, California 96346-5000.
PY - 1989/3
Y1 - 1989/3
N2 - In a year-long, case-control study of endemic diarrheal disease among 1230 Thai children less than five years of age, rotavirus was detected in 20%, Campylobacter in 13%, Shigella in 13%, Salmonella in 12%, and enterotoxigenic Escherichia coli (ETEC) in 9%. The differences in detection of enteric pathogens between patients and controls was significant for rotavirus (P<.001), Shigella (P<.001), ETEC that produced heat-labile and heat-stable toxins (LT and ST; P =.005), and ST only (P <.001). C. jejuni was most significantly associated with diarrhea in children less than 12 years old (P =.037) and Salmonella in children less than three months of age (P =.003). Enteropathogenic E. coli (EPEC) that adhered in a localized pattern to HeLa cells was isolated from 7% of patients and 3% of controls less than six months of age. Only 50% of these E. coli strains were of EPEC serotypes. Enteroinvasive E. coli was isolated from 7% of patients more than two years of age, and new serotypes were identified.
AB - In a year-long, case-control study of endemic diarrheal disease among 1230 Thai children less than five years of age, rotavirus was detected in 20%, Campylobacter in 13%, Shigella in 13%, Salmonella in 12%, and enterotoxigenic Escherichia coli (ETEC) in 9%. The differences in detection of enteric pathogens between patients and controls was significant for rotavirus (P<.001), Shigella (P<.001), ETEC that produced heat-labile and heat-stable toxins (LT and ST; P =.005), and ST only (P <.001). C. jejuni was most significantly associated with diarrhea in children less than 12 years old (P =.037) and Salmonella in children less than three months of age (P =.003). Enteropathogenic E. coli (EPEC) that adhered in a localized pattern to HeLa cells was isolated from 7% of patients and 3% of controls less than six months of age. Only 50% of these E. coli strains were of EPEC serotypes. Enteroinvasive E. coli was isolated from 7% of patients more than two years of age, and new serotypes were identified.
UR - https://www.scopus.com/pages/publications/0024535201
UR - https://www.scopus.com/pages/publications/0024535201#tab=citedBy
U2 - 10.1093/infdis/159.3.543
DO - 10.1093/infdis/159.3.543
M3 - Article
C2 - 2644383
AN - SCOPUS:0024535201
SN - 0022-1899
VL - 159
SP - 543
EP - 548
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -