Abstract
This chapter focuses on spontaneously occurring cardiovascular lesions observed in routine background strains of mice, genetically engineered cardiovascular models, and methods utilized for characterizing cardiovascular disease in mice. It also focuses on anatomical and histological methods for characterizing vessels and hearts. For routine screening type phenotyping necropsies, the heart may remain attached to the thoracic pluck, either removed from the chest or fixed in situ in the opened thoracic cavity with the breastplate sternum removed. Hearts can be dissected into regions and ratios of ventricular weights can provide quantitative data, but dissection of the unfixed heart may result in reduced histology quality with frequent hypercontracted cardiomyocytes. Gene nomenclature for humans and mouse genes are listed. The chapter provides some examples of genetic variants provided by Mouse Genome Informatics. The pathologic response, such as fibrosis, could be induced by multiple different etiologies from viral diseases to genetic diseases.
| Original language | English (US) |
|---|---|
| Title of host publication | Pathology of Genetically Engineered and Other Mutant Mice |
| Publisher | Wiley-Blackwell |
| Pages | 284-306 |
| Number of pages | 23 |
| ISBN (Electronic) | 9781119624608 |
| ISBN (Print) | 9781119624578 |
| DOIs | |
| State | Published - Feb 2 2022 |
Keywords
- Cardiovascular lesions
- Cardiovascular system
- Genetically engineered cardiovascular models
- Histological methods
- Mouse anatomy
ASJC Scopus subject areas
- General Veterinary