TY - JOUR
T1 - Cardiovascular risk prevalence in South Africans with drug-resistant tuberculosis
T2 - A cross-sectional study
AU - Whitehouse, E. R.
AU - Perrin, N.
AU - Levitt, N.
AU - Hill, M.
AU - Farley, J. E.
N1 - Funding Information:
The authors thank R Chaisson for his assistance in developing and refining this research, the parent study team and study participants. This research was supported by the National Institutes of Health (Bethesda, MD, USA; award numbers F31-NR016909 [NINR, EW], R01-AI104488 [NIAID, JF], and Sigma Theta Tau International Research Grant [EW]). Conflicts of interest: none declared.
Publisher Copyright:
© 2019 The Union
PY - 2019
Y1 - 2019
N2 - BACKGROUND: In South Africa, the risk factors for cardiovascular disease (CVD) are increasing, thereby impacting patients with drug-resistant tuberculosis (DR-TB). OBJECTIVE: To determine the prevalence of traditional CVD risk factors (diabetes mellitus [DM], smoking, hypertension, increased body mass index [BMI]) and a total risk score for CVD among patients with DR-TB. METHODS: This cross-sectional study was nested within an ongoing cluster-randomized trial in 10 DR-TB hospitals in South Africa. The data for the present study were collected between November 2014 and July 2016. RESULTS: Of 900 participants aged 718 years, 75.1% were co-infected with the human immunodeficiency virus (HIV), and 52.3% had one or more CVD risk factors. The prevalence of CVD risk factors was hypertension (16.7%), increased BMI (16.6%), DM (5.2%), and smoking (31.4%). Among patients with DM or hypertension, 58.8-95.5% had additional comorbid CVD risk factors. Of 398 participants eligible for the CVD risk score (age 7 35 years), 23.4% had a moderate or high CVD risk score. CONCLUSION: Patients with multiple diseases, including DR-TB and HIV, with traditional CVD risk factors, may have higher risks for negative outcomes during treatment for DR-TB. TB providers should identify people at risk to initiate primary and secondary prevention to improve outcomes.
AB - BACKGROUND: In South Africa, the risk factors for cardiovascular disease (CVD) are increasing, thereby impacting patients with drug-resistant tuberculosis (DR-TB). OBJECTIVE: To determine the prevalence of traditional CVD risk factors (diabetes mellitus [DM], smoking, hypertension, increased body mass index [BMI]) and a total risk score for CVD among patients with DR-TB. METHODS: This cross-sectional study was nested within an ongoing cluster-randomized trial in 10 DR-TB hospitals in South Africa. The data for the present study were collected between November 2014 and July 2016. RESULTS: Of 900 participants aged 718 years, 75.1% were co-infected with the human immunodeficiency virus (HIV), and 52.3% had one or more CVD risk factors. The prevalence of CVD risk factors was hypertension (16.7%), increased BMI (16.6%), DM (5.2%), and smoking (31.4%). Among patients with DM or hypertension, 58.8-95.5% had additional comorbid CVD risk factors. Of 398 participants eligible for the CVD risk score (age 7 35 years), 23.4% had a moderate or high CVD risk score. CONCLUSION: Patients with multiple diseases, including DR-TB and HIV, with traditional CVD risk factors, may have higher risks for negative outcomes during treatment for DR-TB. TB providers should identify people at risk to initiate primary and secondary prevention to improve outcomes.
KW - Cardiovascular risk score
KW - DR-TB
KW - Diabetes
KW - Hypertension
KW - Smoking
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U2 - 10.5588/ijtld.18.0374
DO - 10.5588/ijtld.18.0374
M3 - Article
C2 - 31097067
AN - SCOPUS:85066872754
SN - 1027-3719
VL - 23
SP - 587
EP - 593
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
IS - 5
ER -