TY - JOUR
T1 - Cardiovascular interactions of desipramine, fluoxetine, and cocaine in cocaine-dependent outpatients
AU - Nelson, Richard A.
AU - Gorelick, David A.
AU - Keenan, Robert M.
AU - Carmona, Gilberto N.
AU - Covi, Lino
PY - 1996
Y1 - 1996
N2 - The authors investigated the subacute cardiovascular effects of cocaine use alone and with antidepressants. At study entry, 55 cocaine-dependent (DSM-III-R) patients with cocaine-positive urines had slightly higher resting heart rates and blood pressures than 36 patients with cocaine-negative urines, which achieved significance (P < 0.05) for three of eleven parameters. A repeated-measures analysis of medication-compliant patients found no significant cardiovascular differences between cocaine-positive and cocaine-negative urine conditions for either desipramine (n = 10) or fluoxetine (n = 20). Cocaine use appears to produce minimal subacute cardiovascular effects, which are not accentuated by desipramine or fluoxetine, in physically healthy cocaine-dependent patients.
AB - The authors investigated the subacute cardiovascular effects of cocaine use alone and with antidepressants. At study entry, 55 cocaine-dependent (DSM-III-R) patients with cocaine-positive urines had slightly higher resting heart rates and blood pressures than 36 patients with cocaine-negative urines, which achieved significance (P < 0.05) for three of eleven parameters. A repeated-measures analysis of medication-compliant patients found no significant cardiovascular differences between cocaine-positive and cocaine-negative urine conditions for either desipramine (n = 10) or fluoxetine (n = 20). Cocaine use appears to produce minimal subacute cardiovascular effects, which are not accentuated by desipramine or fluoxetine, in physically healthy cocaine-dependent patients.
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U2 - 10.1111/j.1521-0391.1996.tb00318.x
DO - 10.1111/j.1521-0391.1996.tb00318.x
M3 - Article
AN - SCOPUS:0029846975
SN - 1055-0496
VL - 5
SP - 321
EP - 326
JO - American Journal on Addictions
JF - American Journal on Addictions
IS - 4
ER -