Cardiovascular interactions of desipramine, fluoxetine, and cocaine in cocaine-dependent outpatients

Richard A. Nelson, David A. Gorelick, Robert M. Keenan, Gilberto N. Carmona, Lino Covi

Research output: Contribution to journalArticlepeer-review


The authors investigated the subacute cardiovascular effects of cocaine use alone and with antidepressants. At study entry, 55 cocaine-dependent (DSM-III-R) patients with cocaine-positive urines had slightly higher resting heart rates and blood pressures than 36 patients with cocaine-negative urines, which achieved significance (P < 0.05) for three of eleven parameters. A repeated-measures analysis of medication-compliant patients found no significant cardiovascular differences between cocaine-positive and cocaine-negative urine conditions for either desipramine (n = 10) or fluoxetine (n = 20). Cocaine use appears to produce minimal subacute cardiovascular effects, which are not accentuated by desipramine or fluoxetine, in physically healthy cocaine-dependent patients.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalAmerican Journal on Addictions
Issue number4
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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