Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat

Peter D. Feldman; Nibras Parveen; Sena Sezen

doi:10.1016/0006-8993(95)01434-9

Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat

Peter D. Feldman, Nibras Parveen, Sena Sezen

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for μ receptors, and the δ antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of δ-, and possibly μ-, opioid receptors in the dorsal vagal complex.

Original language	English (US)
Pages (from-to)	331-336
Number of pages	6
Journal	Brain Research
Volume	709
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(95)01434-9
State	Published - Feb 19 1996
Externally published	Yes

Keywords

δ
μ
Autonomic
Enkephalin
ICI 154,129
Naloxone
Opioid
Solitarius
Vagal

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0006-8993(95)01434-9

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title = "Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat",

abstract = "Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for μ receptors, and the δ antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of δ-, and possibly μ-, opioid receptors in the dorsal vagal complex.",

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T1 - Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat

AU - Feldman, Peter D.

AU - Parveen, Nibras

AU - Sezen, Sena

PY - 1996/2/19

Y1 - 1996/2/19

N2 - Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for μ receptors, and the δ antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of δ-, and possibly μ-, opioid receptors in the dorsal vagal complex.

AB - Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for μ receptors, and the δ antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of δ-, and possibly μ-, opioid receptors in the dorsal vagal complex.

KW - δ

KW - μ

KW - Autonomic

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KW - Naloxone

KW - Opioid

KW - Solitarius

KW - Vagal

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Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat

Abstract

Keywords

ASJC Scopus subject areas

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