Cardiovascular Disease Associated with the Human Immunodeficiency Virus: An Update

Thomas Metkus; Todd T. Brown; Wendy Post

doi:10.1007/s11936-014-0346-x

Cardiovascular Disease Associated with the Human Immunodeficiency Virus: An Update

Thomas Metkus, Todd T. Brown, Wendy Post

School of Medicine

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

With the advent of increasingly available antiretroviral therapy (ART), the life expectancy of HIV-infected persons is increasing. As they age, HIV-infected persons have increased propensity to typical diseases of aging including cardiovascular disease and accelerated atherosclerosis. The pathogenesis of HIV-associated atherosclerosis is complex and involves a state of chronic inflammation, exposure to traditional risk factors, and metabolic side effects of ART. Treatment of HIV-associated atherosclerosis should include special attention to drug-drug interactions and is best accomplished by a multidisciplinary team experienced in the care of HIV-infected persons.

Original language	English (US)
Article number	346
Pages (from-to)	1-11
Number of pages	11
Journal	Current Treatment Options in Cardiovascular Medicine
Volume	16
Issue number	11
DOIs	https://doi.org/10.1007/s11936-014-0346-x
State	Published - Nov 1 2014

Keywords

Antiretroviral therapy
Cardiovascular disease
Human immunodeficiency virus
Prevention

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1007/s11936-014-0346-x

Cite this

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title = "Cardiovascular Disease Associated with the Human Immunodeficiency Virus: An Update",

abstract = "With the advent of increasingly available antiretroviral therapy (ART), the life expectancy of HIV-infected persons is increasing. As they age, HIV-infected persons have increased propensity to typical diseases of aging including cardiovascular disease and accelerated atherosclerosis. The pathogenesis of HIV-associated atherosclerosis is complex and involves a state of chronic inflammation, exposure to traditional risk factors, and metabolic side effects of ART. Treatment of HIV-associated atherosclerosis should include special attention to drug-drug interactions and is best accomplished by a multidisciplinary team experienced in the care of HIV-infected persons.",

keywords = "Antiretroviral therapy, Cardiovascular disease, Human immunodeficiency virus, Prevention",

author = "Thomas Metkus and Brown, {Todd T.} and Wendy Post",

note = "Funding Information: Dr Thomas Metkus and Dr Todd T. Brown each declare no potential conflicts of interest. Dr Wendy Post reports grants from NIH. Publisher Copyright: {\textcopyright} 2014, Springer Science+Business Media New York.",

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AU - Metkus, Thomas

AU - Brown, Todd T.

AU - Post, Wendy

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N2 - With the advent of increasingly available antiretroviral therapy (ART), the life expectancy of HIV-infected persons is increasing. As they age, HIV-infected persons have increased propensity to typical diseases of aging including cardiovascular disease and accelerated atherosclerosis. The pathogenesis of HIV-associated atherosclerosis is complex and involves a state of chronic inflammation, exposure to traditional risk factors, and metabolic side effects of ART. Treatment of HIV-associated atherosclerosis should include special attention to drug-drug interactions and is best accomplished by a multidisciplinary team experienced in the care of HIV-infected persons.

AB - With the advent of increasingly available antiretroviral therapy (ART), the life expectancy of HIV-infected persons is increasing. As they age, HIV-infected persons have increased propensity to typical diseases of aging including cardiovascular disease and accelerated atherosclerosis. The pathogenesis of HIV-associated atherosclerosis is complex and involves a state of chronic inflammation, exposure to traditional risk factors, and metabolic side effects of ART. Treatment of HIV-associated atherosclerosis should include special attention to drug-drug interactions and is best accomplished by a multidisciplinary team experienced in the care of HIV-infected persons.

KW - Antiretroviral therapy

KW - Cardiovascular disease

KW - Human immunodeficiency virus

KW - Prevention

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Cardiovascular Disease Associated with the Human Immunodeficiency Virus: An Update

Abstract

Keywords

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