Cardiotoxicity and hypertension in rats after oral lead exposure

B. Lai; R. C. Murthy; Mohini Anand; S. V. Chandra; Rajiv Kumar; O. Tripathi; R. C. Srimal

doi:10.3109/01480549109002192

Cardiotoxicity and hypertension in rats after oral lead exposure

B. Lai, R. C. Murthy, Mohini Anand, S. V. Chandra, Rajiv Kumar, O. Tripathi, R. C. Srimal

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The rats were exposed to lead (0.25, 0.5 and 1.0 per cent lead acetate through drinking water) for 90 days to study its effect on some physiological and morphological parameters of the cardiovascular system. Blood lead levels increased in a dose dependent manner but heart tissue showed rise at only two higher doses in exposed animals. the two higher doses of lead resulted in an increased arterial blood pressure and calcium influx in atrial trabeculae and papillary muscles. No marked pathological or histochemical changes were observed in heart tissue excepting congestion and slightly reduced activity of succinic dehydrogenase in the highest dosed group. It was concluded that lead exposure through drinking water may produce increased arterial blood pressure and Minor changes in the myocardium. Whether these changes are mediated through the effect of lead on the calcium transport needs further investigation.

Original language	English (US)
Pages (from-to)	305-318
Number of pages	14
Journal	Drug and Chemical Toxicology
Volume	14
Issue number	3
DOIs	https://doi.org/10.3109/01480549109002192
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis
Toxicology
Chemical Health and Safety
Pharmacology

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abstract = "The rats were exposed to lead (0.25, 0.5 and 1.0 per cent lead acetate through drinking water) for 90 days to study its effect on some physiological and morphological parameters of the cardiovascular system. Blood lead levels increased in a dose dependent manner but heart tissue showed rise at only two higher doses in exposed animals. the two higher doses of lead resulted in an increased arterial blood pressure and calcium influx in atrial trabeculae and papillary muscles. No marked pathological or histochemical changes were observed in heart tissue excepting congestion and slightly reduced activity of succinic dehydrogenase in the highest dosed group. It was concluded that lead exposure through drinking water may produce increased arterial blood pressure and Minor changes in the myocardium. Whether these changes are mediated through the effect of lead on the calcium transport needs further investigation.",

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T1 - Cardiotoxicity and hypertension in rats after oral lead exposure

AU - Lai, B.

AU - Murthy, R. C.

AU - Anand, Mohini

AU - Chandra, S. V.

AU - Kumar, Rajiv

AU - Tripathi, O.

AU - Srimal, R. C.

PY - 1991

Y1 - 1991

N2 - The rats were exposed to lead (0.25, 0.5 and 1.0 per cent lead acetate through drinking water) for 90 days to study its effect on some physiological and morphological parameters of the cardiovascular system. Blood lead levels increased in a dose dependent manner but heart tissue showed rise at only two higher doses in exposed animals. the two higher doses of lead resulted in an increased arterial blood pressure and calcium influx in atrial trabeculae and papillary muscles. No marked pathological or histochemical changes were observed in heart tissue excepting congestion and slightly reduced activity of succinic dehydrogenase in the highest dosed group. It was concluded that lead exposure through drinking water may produce increased arterial blood pressure and Minor changes in the myocardium. Whether these changes are mediated through the effect of lead on the calcium transport needs further investigation.

AB - The rats were exposed to lead (0.25, 0.5 and 1.0 per cent lead acetate through drinking water) for 90 days to study its effect on some physiological and morphological parameters of the cardiovascular system. Blood lead levels increased in a dose dependent manner but heart tissue showed rise at only two higher doses in exposed animals. the two higher doses of lead resulted in an increased arterial blood pressure and calcium influx in atrial trabeculae and papillary muscles. No marked pathological or histochemical changes were observed in heart tissue excepting congestion and slightly reduced activity of succinic dehydrogenase in the highest dosed group. It was concluded that lead exposure through drinking water may produce increased arterial blood pressure and Minor changes in the myocardium. Whether these changes are mediated through the effect of lead on the calcium transport needs further investigation.

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Cardiotoxicity and hypertension in rats after oral lead exposure

Abstract

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