Cardiospheres and cardiosphere-derived cells as therapeutic agents following myocardial infarction

Michelle Kreke, Rachel Ruckdeschel Smith, Linda Marbán, Eduardo Marbán

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Heart disease is a major cause of morbidity and mortality. Cellular therapies hold significant promise for patients with heart disease. Heart-derived progenitor cells are capable of repairing a diseased heart through modulation of growth factor milieu and temporary engraftment leading to endogenous repair. The proof-of-concept CADUCEUS clinical trial using cardiosphere-derived cells has shown evidence of therapeutic cardiac tissue regeneration. Future clinical trials are now being planned to generate additional safety and efficacy data in the hopes of building toward an approved cellular therapy for heart disease.

Original languageEnglish (US)
Pages (from-to)1185-1194
Number of pages10
JournalExpert Review of Cardiovascular Therapy
Issue number9
StatePublished - Sep 2012
Externally publishedYes


  • allogeneic
  • autologous
  • cardiac tissue derived
  • cardiosphere-derived cells
  • cardiospheres
  • cellular therapy
  • heart disease
  • intracoronary infusion
  • intramuscular injection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine


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