Cardiorespiratory physiology in the safe passage study: protocol, methods and normative values in unexposed infants

PASS Network

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Aim: The Safe Passage Study, conducted by the Prenatal Alcohol in SIDS and Stillbirth Network, is investigating contributions of prenatal alcohol exposure to foetal and infant demise. This current report presents physiological data from full-term infants with no prenatal exposure to alcohol or maternal smoking. Methods: Data are from 666 infants from the Northern Plains (North and South Dakota) and South Africa. A standardised protocol assessed cardiorespiratory function during baseline and head-up tilts shortly after birth and at one month of age. Results: Analyses revealed significant increases in heart rate and decreases in BP from the newborn to one-month time period as well as diminished heart rate responses to head-up tilt in one-month-old infants. Conclusion: The Safe Passage Study was successful in characterising physiology in a large number of infants at sites known to have elevated risks for SIDS. Results demonstrate that even with low prenatal adverse exposures, there are significant changes in cardiorespiratory function as infants enter the window of increased risk for SIDS.

Original languageEnglish (US)
Pages (from-to)1260-1272
Number of pages13
JournalActa Paediatrica, International Journal of Paediatrics
Issue number8
StatePublished - Aug 2017
Externally publishedYes


  • Autonomic development
  • Blood pressure
  • Heart rate
  • Respiration
  • SIDS

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Cardiorespiratory physiology in the safe passage study: protocol, methods and normative values in unexposed infants'. Together they form a unique fingerprint.

Cite this