Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease

Clayton J. Vesperman; Rui Wang; Stephanie A. Schultz; Lena L. Law; Ryan J. Dougherty; Yue Ma; Jennifer M. Oh; Dorothy F. Edwards; Catherine L. Gallagher; Nathaniel A. Chin; Sanjay Asthana; Bruce P. Hermann; Mark A. Sager; Sterling C. Johnson; Dane B. Cook; Ozioma C. Okonkwo

doi:10.1002/dad2.12330

Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease

Clayton J. Vesperman, Rui Wang, Stephanie A. Schultz, Lena L. Law, Ryan J. Dougherty, Yue Ma, Jennifer M. Oh, Dorothy F. Edwards, Catherine L. Gallagher, Nathaniel A. Chin, Sanjay Asthana, Bruce P. Hermann, Mark A. Sager, Sterling C. Johnson, Dane B. Cook, Ozioma C. Okonkwo

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: This study examined the relationship between cardiorespiratory fitness (CRF) and longitudinal cognitive functioning in a cohort enriched with risk factors for Alzheimer's disease (AD). Methods: A total of 155 enrollees in the Wisconsin Registry for Alzheimer's Prevention completed repeat comprehensive neuropsychological evaluations that assessed six cognitive domains. Peak oxygen consumption (VO₂peak) was the primary measure of CRF. Random effects regression was used to investigate the effect of CRF on cognitive trajectories. Results: Higher CRF was associated with slower decline in the cognitive domains of verbal learning and memory (P <.01) and visual learning and memory (P <.042). Secondary analyses indicated that these effects were stronger among men than women, and for noncarriers of the apolipoprotein E ε4 allele. Discussion: Higher CRF was associated with a slower rate of the decline in episodic memory that occurs as a natural consequence of aging in a cohort enriched with risk factors for AD.

Original language	English (US)
Article number	e12330
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	14
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12330
State	Published - 2022
Externally published	Yes

Keywords

aging
cognition
episodic memory
exercise test
humans
neuropsychological tests

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1002/dad2.12330

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Vesperman, C. J., Wang, R., Schultz, S. A., Law, L. L., Dougherty, R. J., Ma, Y., Oh, J. M., Edwards, D. F., Gallagher, C. L., Chin, N. A., Asthana, S., Hermann, B. P., Sager, M. A., Johnson, S. C., Cook, D. B., & Okonkwo, O. C. (2022). Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 14(1), Article e12330. https://doi.org/10.1002/dad2.12330

Vesperman, CJ, Wang, R, Schultz, SA, Law, LL, Dougherty, RJ, Ma, Y, Oh, JM, Edwards, DF, Gallagher, CL, Chin, NA, Asthana, S, Hermann, BP, Sager, MA, Johnson, SC, Cook, DB & Okonkwo, OC 2022, 'Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 14, no. 1, e12330. https://doi.org/10.1002/dad2.12330

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title = "Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease",

abstract = "Introduction: This study examined the relationship between cardiorespiratory fitness (CRF) and longitudinal cognitive functioning in a cohort enriched with risk factors for Alzheimer's disease (AD). Methods: A total of 155 enrollees in the Wisconsin Registry for Alzheimer's Prevention completed repeat comprehensive neuropsychological evaluations that assessed six cognitive domains. Peak oxygen consumption (VO2peak) was the primary measure of CRF. Random effects regression was used to investigate the effect of CRF on cognitive trajectories. Results: Higher CRF was associated with slower decline in the cognitive domains of verbal learning and memory (P <.01) and visual learning and memory (P <.042). Secondary analyses indicated that these effects were stronger among men than women, and for noncarriers of the apolipoprotein E ε4 allele. Discussion: Higher CRF was associated with a slower rate of the decline in episodic memory that occurs as a natural consequence of aging in a cohort enriched with risk factors for AD.",

keywords = "aging, cognition, episodic memory, exercise test, humans, neuropsychological tests",

author = "Vesperman, {Clayton J.} and Rui Wang and Schultz, {Stephanie A.} and Law, {Lena L.} and Dougherty, {Ryan J.} and Yue Ma and Oh, {Jennifer M.} and Edwards, {Dorothy F.} and Gallagher, {Catherine L.} and Chin, {Nathaniel A.} and Sanjay Asthana and Hermann, {Bruce P.} and Sager, {Mark A.} and Johnson, {Sterling C.} and Cook, {Dane B.} and Okonkwo, {Ozioma C.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.",

year = "2022",

doi = "10.1002/dad2.12330",

language = "English (US)",

volume = "14",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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T1 - Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease

AU - Vesperman, Clayton J.

AU - Wang, Rui

AU - Schultz, Stephanie A.

AU - Law, Lena L.

AU - Dougherty, Ryan J.

AU - Ma, Yue

AU - Oh, Jennifer M.

AU - Edwards, Dorothy F.

AU - Gallagher, Catherine L.

AU - Chin, Nathaniel A.

AU - Asthana, Sanjay

AU - Hermann, Bruce P.

AU - Sager, Mark A.

AU - Johnson, Sterling C.

AU - Cook, Dane B.

AU - Okonkwo, Ozioma C.

PY - 2022

Y1 - 2022

N2 - Introduction: This study examined the relationship between cardiorespiratory fitness (CRF) and longitudinal cognitive functioning in a cohort enriched with risk factors for Alzheimer's disease (AD). Methods: A total of 155 enrollees in the Wisconsin Registry for Alzheimer's Prevention completed repeat comprehensive neuropsychological evaluations that assessed six cognitive domains. Peak oxygen consumption (VO2peak) was the primary measure of CRF. Random effects regression was used to investigate the effect of CRF on cognitive trajectories. Results: Higher CRF was associated with slower decline in the cognitive domains of verbal learning and memory (P <.01) and visual learning and memory (P <.042). Secondary analyses indicated that these effects were stronger among men than women, and for noncarriers of the apolipoprotein E ε4 allele. Discussion: Higher CRF was associated with a slower rate of the decline in episodic memory that occurs as a natural consequence of aging in a cohort enriched with risk factors for AD.

AB - Introduction: This study examined the relationship between cardiorespiratory fitness (CRF) and longitudinal cognitive functioning in a cohort enriched with risk factors for Alzheimer's disease (AD). Methods: A total of 155 enrollees in the Wisconsin Registry for Alzheimer's Prevention completed repeat comprehensive neuropsychological evaluations that assessed six cognitive domains. Peak oxygen consumption (VO2peak) was the primary measure of CRF. Random effects regression was used to investigate the effect of CRF on cognitive trajectories. Results: Higher CRF was associated with slower decline in the cognitive domains of verbal learning and memory (P <.01) and visual learning and memory (P <.042). Secondary analyses indicated that these effects were stronger among men than women, and for noncarriers of the apolipoprotein E ε4 allele. Discussion: Higher CRF was associated with a slower rate of the decline in episodic memory that occurs as a natural consequence of aging in a cohort enriched with risk factors for AD.

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KW - episodic memory

KW - exercise test

KW - humans

KW - neuropsychological tests

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Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease

Abstract

Keywords

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