Cardiac stem/progenitor cells, secreted proteins, and proteomics

Miroslava Stastna; M. Roselle Abraham; Jennifer E. Van Eyk

doi:10.1016/j.febslet.2009.03.026

Cardiac stem/progenitor cells, secreted proteins, and proteomics

Miroslava Stastna, M. Roselle Abraham, Jennifer E. Van Eyk

Research output: Contribution to journal › Short survey › peer-review

36 Scopus citations

Abstract

Stem cell-based therapy is emerging as a novel approach for myocardial repair over conventional cardiovascular therapies. In addition to embryonic stem cells and adult stem cells from noncardiac sources, there is a small population of resident stem cells in the heart from which new cardiac cells (myocytes, vascular endothelial cells and smooth muscle cells) can be derived and used for cardiac repair in case of heart injury. It has been proposed that the clinical benefit of stem cells may arise from secreted proteins that mediate regeneration in a paracrine/autocrine manner. To be able to track the regulatory pathway on a molecular basis, utilization of proteomics in stem cell research is essential. Proteomics offers a tool that can address questions regarding stem cell response to disease/injury.

Original language	English (US)
Pages (from-to)	1800-1807
Number of pages	8
Journal	FEBS Letters
Volume	583
Issue number	11
DOIs	https://doi.org/10.1016/j.febslet.2009.03.026
State	Published - Jun 5 2009
Externally published	Yes

Keywords

Cardiac stem/progenitor cell
Paracrine factor
Proteomics
Secretome

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2009.03.026

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title = "Cardiac stem/progenitor cells, secreted proteins, and proteomics",

abstract = "Stem cell-based therapy is emerging as a novel approach for myocardial repair over conventional cardiovascular therapies. In addition to embryonic stem cells and adult stem cells from noncardiac sources, there is a small population of resident stem cells in the heart from which new cardiac cells (myocytes, vascular endothelial cells and smooth muscle cells) can be derived and used for cardiac repair in case of heart injury. It has been proposed that the clinical benefit of stem cells may arise from secreted proteins that mediate regeneration in a paracrine/autocrine manner. To be able to track the regulatory pathway on a molecular basis, utilization of proteomics in stem cell research is essential. Proteomics offers a tool that can address questions regarding stem cell response to disease/injury.",

keywords = "Cardiac stem/progenitor cell, Paracrine factor, Proteomics, Secretome",

author = "Miroslava Stastna and Abraham, {M. Roselle} and {Van Eyk}, {Jennifer E.}",

note = "Funding Information: This study was supported by the National Heart, Lung, and Blood Institute Proteomic Initiative – Contract N01-HV-28180 (J.V.E.), by the Institutional Research Plan AV0Z40310501 of the Academy of Sciences of the Czech Republic (M.S.) and by the WW Smith Foundation grant (M.R.A.).",

year = "2009",

month = jun,

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doi = "10.1016/j.febslet.2009.03.026",

language = "English (US)",

volume = "583",

pages = "1800--1807",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "11",

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T1 - Cardiac stem/progenitor cells, secreted proteins, and proteomics

AU - Stastna, Miroslava

AU - Abraham, M. Roselle

AU - Van Eyk, Jennifer E.

N1 - Funding Information: This study was supported by the National Heart, Lung, and Blood Institute Proteomic Initiative – Contract N01-HV-28180 (J.V.E.), by the Institutional Research Plan AV0Z40310501 of the Academy of Sciences of the Czech Republic (M.S.) and by the WW Smith Foundation grant (M.R.A.).

PY - 2009/6/5

Y1 - 2009/6/5

N2 - Stem cell-based therapy is emerging as a novel approach for myocardial repair over conventional cardiovascular therapies. In addition to embryonic stem cells and adult stem cells from noncardiac sources, there is a small population of resident stem cells in the heart from which new cardiac cells (myocytes, vascular endothelial cells and smooth muscle cells) can be derived and used for cardiac repair in case of heart injury. It has been proposed that the clinical benefit of stem cells may arise from secreted proteins that mediate regeneration in a paracrine/autocrine manner. To be able to track the regulatory pathway on a molecular basis, utilization of proteomics in stem cell research is essential. Proteomics offers a tool that can address questions regarding stem cell response to disease/injury.

AB - Stem cell-based therapy is emerging as a novel approach for myocardial repair over conventional cardiovascular therapies. In addition to embryonic stem cells and adult stem cells from noncardiac sources, there is a small population of resident stem cells in the heart from which new cardiac cells (myocytes, vascular endothelial cells and smooth muscle cells) can be derived and used for cardiac repair in case of heart injury. It has been proposed that the clinical benefit of stem cells may arise from secreted proteins that mediate regeneration in a paracrine/autocrine manner. To be able to track the regulatory pathway on a molecular basis, utilization of proteomics in stem cell research is essential. Proteomics offers a tool that can address questions regarding stem cell response to disease/injury.

KW - Cardiac stem/progenitor cell

KW - Paracrine factor

KW - Proteomics

KW - Secretome

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DO - 10.1016/j.febslet.2009.03.026

M3 - Short survey

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SN - 0014-5793

VL - 583

SP - 1800

EP - 1807

JO - FEBS Letters

JF - FEBS Letters

IS - 11

ER -

Cardiac stem/progenitor cells, secreted proteins, and proteomics

Abstract

Keywords

ASJC Scopus subject areas

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