Cardiac biomarkers and acute kidney injury after cardiac surgery

Emily M. Bucholz, Richard P. Whitlock, Michael Zappitelli, Prasad Devarajan, John Eikelboom, Amit X. Garg, Heather Thiessen Philbrook, Philip J. Devereaux, Catherine D. Krawczeski, Peter Kavsak, Colleen Shorttk, Chirag R. Parikh

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


OBJECTIVES: To examine the relationship of cardiac biomarkers with postoperative acute kidney abstract injury (AKI) among pediatric patients undergoing cardiac surgery. METHODS: Data from TRIBE-AKI, a prospective study of children undergoing cardiac surgery, were used to examine the association of cardiac biomarkers (N-type pro-B-type natriuretic peptide, creatine kinase-MB [CK-MB], heart-type fatty acid binding protein [h-FABP], and troponins I and T) with the development of postoperative AKI. Cardiac biomarkers were collected before and 0 to 6 hours after surgery. AKI was defined as a ≥50% or 0.3 mg/dL increase in serum creatinine, within 7 days of surgery. RESULTS: Of the 106 patients included in this study, 55 (52%) developed AKI after cardiac surgery. Patients who developed AKI had higher median levels of pre- and postoperative cardiac biomarkers compared with patients without AKI (all P <.01). Preoperatively, higher levels of CK-MB and h-FABP were associated with increased odds of developing AKI (CK-MB: adjusted odds ratio 4.58, 95% confidence interval [CI] 1.56-13.41; h-FABP: adjusted odds ratio 2.76, 95% CI 1.27-6.03). When combined with clinical models, both preoperative CK-MB and h-FABP provided good discrimination (area under the curve 0.77, 95% CI 0.68-0.87, and 0.78, 95% CI 0.68-0.87, respectively) and improved reclassification indices. Cardiac biomarkers collected postoperatively did not significantly improve the prediction of AKI beyond clinical models. CONCLUSIONS: Preoperative CK-MB and h-FABP are associated with increased risk of postoperative AKI and provide good discrimination of patients who develop AKI. These biomarkers may be useful for risk stratifying patients undergoing cardiac surgery.

Original languageEnglish (US)
Pages (from-to)e945-e956
Issue number4
StatePublished - Apr 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Cardiac biomarkers and acute kidney injury after cardiac surgery'. Together they form a unique fingerprint.

Cite this