Carbon monoxide diffusing capacity as predictor of outcome in systemic sclerosis

Marc Peters-Golden, Robert A. Wise, Marc C. Hochberg, Mary Betty Stevens, Fredrick M. Wigley

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


In order to determine the predictive value of lung function studies for subsequent prognosis in systemic sclerosis, 71 patients with systemic sclerosis were followed up for a mean of five years after pulmonary function testing. A carbon monoxide diffusing capacity less than or equal to 40 percent of the predicted reference value was associated with only a 9 percent five-year cumulative survival rate compared with a 75 percent cumulative five-year survival in patients with a carbon monoxide diffusing capacity greater than 40 percent of predicted. An obstructive ventilatory defect was also associated with increased mortality, and all six patients with obstruction and a diffusing capacity less than 70 percent of the predicted died during the study period. Male gender, independent of abnormalities of pulmonary function, was also associated with a poor prognosis. Although it is not clear whether a severely impaired diffusing capacity is indicative of interstitial pulmonary fibrosis or pulmonary vasculopathy or is a marker of generalized vascular disease, a severely depressed carbon monoxide diffusing capacity is an important predictor of mortality in patients with systemic sclerosis.

Original languageEnglish (US)
Pages (from-to)1027-1034
Number of pages8
JournalThe American journal of medicine
Issue number6
StatePublished - Dec 1984
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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