Carbon dioxide prevents pulmonary overcirculation in hypoplastic left heart syndrome

David R. Jobes, Susan C. Nicolson, James M. Steven, Margaret Miller, Marshall L. Jacobs, William I. Norwood

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


Circulatory and metabolic homeostasis in patients with hypoplastic left heart syndrome is dependent on a delicate balance between systemic and pulmonary blood flow. Hypocarbia can result in a marked decrease in pulmonary vascular resistance accompanied by pulmonary overcirculation, systemic hypotension, metabolic acidosis, and death. This report illustrates that early and precise control of the arterial carbon dioxide tension using inspired carbon dioxide can be effective in preventing or treating instability arising during management of a patient with hypoplastic left heart syndrome.

Original languageEnglish (US)
Pages (from-to)150-151
Number of pages2
JournalThe Annals of thoracic surgery
Issue number1
StatePublished - Jul 1992
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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