Carbon-11 labeled radioligands for imaging brain cannabinoid receptors

William B. Mathews; Ursula Scheffel; Paige A. Rauseo; Hayden T. Ravert; Richard A. Frank; George J. Ellames; John M. Herbert; Francis Barth; Murielle Rinaldi-Carmona; Robert F. Dannals

doi:10.1016/S0969-8051(02)00308-6

Carbon-11 labeled radioligands for imaging brain cannabinoid receptors

William B. Mathews, Ursula Scheffel, Paige A. Rauseo, Hayden T. Ravert, Richard A. Frank, George J. Ellames, John M. Herbert, Francis Barth, Murielle Rinaldi-Carmona, Robert F. Dannals

School of Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Two radioligands, [¹¹C] SR149080 and its morpholino analog [¹¹C] SR149568, were synthesized by reaction of the respective phenolic precursors with [¹¹C] methyl iodide. Both radioligands had appropriate regional brain distribution for cannabinoid receptors in mice with peak target to non-target ratios of 2.2 for [¹¹C] SR149080 and 1.6 for [¹¹C] SR149568 at 90 and 30 minutes post-injection respectively. The uptake of both tracers was blocked with a 1 mg/kg dose of SR141716A.

Original language	English (US)
Pages (from-to)	671-677
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	29
Issue number	6
DOIs	https://doi.org/10.1016/S0969-8051(02)00308-6
State	Published - Aug 2002

Keywords

Antagonist
CB1
Cannabinoid
Carbon-11
Mice
PET

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1016/S0969-8051(02)00308-6

Cite this

@article{8231bdcb1cf049ceaf5a33c57ca5f0dd,

title = "Carbon-11 labeled radioligands for imaging brain cannabinoid receptors",

abstract = "Two radioligands, [11C] SR149080 and its morpholino analog [11C] SR149568, were synthesized by reaction of the respective phenolic precursors with [11C] methyl iodide. Both radioligands had appropriate regional brain distribution for cannabinoid receptors in mice with peak target to non-target ratios of 2.2 for [11C] SR149080 and 1.6 for [11C] SR149568 at 90 and 30 minutes post-injection respectively. The uptake of both tracers was blocked with a 1 mg/kg dose of SR141716A.",

keywords = "Antagonist, CB1, Cannabinoid, Carbon-11, Mice, PET",

author = "Mathews, {William B.} and Ursula Scheffel and Rauseo, {Paige A.} and Ravert, {Hayden T.} and Frank, {Richard A.} and Ellames, {George J.} and Herbert, {John M.} and Francis Barth and Murielle Rinaldi-Carmona and Dannals, {Robert F.}",

year = "2002",

month = aug,

doi = "10.1016/S0969-8051(02)00308-6",

language = "English (US)",

volume = "29",

pages = "671--677",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Carbon-11 labeled radioligands for imaging brain cannabinoid receptors

AU - Mathews, William B.

AU - Scheffel, Ursula

AU - Rauseo, Paige A.

AU - Ravert, Hayden T.

AU - Frank, Richard A.

AU - Ellames, George J.

AU - Herbert, John M.

AU - Barth, Francis

AU - Rinaldi-Carmona, Murielle

AU - Dannals, Robert F.

PY - 2002/8

Y1 - 2002/8

N2 - Two radioligands, [11C] SR149080 and its morpholino analog [11C] SR149568, were synthesized by reaction of the respective phenolic precursors with [11C] methyl iodide. Both radioligands had appropriate regional brain distribution for cannabinoid receptors in mice with peak target to non-target ratios of 2.2 for [11C] SR149080 and 1.6 for [11C] SR149568 at 90 and 30 minutes post-injection respectively. The uptake of both tracers was blocked with a 1 mg/kg dose of SR141716A.

AB - Two radioligands, [11C] SR149080 and its morpholino analog [11C] SR149568, were synthesized by reaction of the respective phenolic precursors with [11C] methyl iodide. Both radioligands had appropriate regional brain distribution for cannabinoid receptors in mice with peak target to non-target ratios of 2.2 for [11C] SR149080 and 1.6 for [11C] SR149568 at 90 and 30 minutes post-injection respectively. The uptake of both tracers was blocked with a 1 mg/kg dose of SR141716A.

KW - Antagonist

KW - CB1

KW - Cannabinoid

KW - Carbon-11

KW - Mice

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=0036701658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036701658&partnerID=8YFLogxK

U2 - 10.1016/S0969-8051(02)00308-6

DO - 10.1016/S0969-8051(02)00308-6

M3 - Article

C2 - 12234592

AN - SCOPUS:0036701658

SN - 0969-8051

VL - 29

SP - 671

EP - 677

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 6

ER -

Carbon-11 labeled radioligands for imaging brain cannabinoid receptors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this