TY - JOUR
T1 - Carbapenem-Resistant Enterobacteriaceae Infections in Children
AU - Chiotos, Kathleen
AU - Han, Jennifer H.
AU - Tamma, Pranita D.
N1 - Funding Information:
This work was supported by the National Institutes of Health (T32HD060550 to K.C. and K01-AI103028 to J.H.H.) and the Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases, Division of Infectious Diseases of The Johns Hopkins University School of Medicine
Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging global public health threat. Infections due to CRE are associated with significant morbidity and mortality. Few therapeutic options are available for treatment of these infections, and optimal antibiotic treatment regimens are unclear. Along with the rapidly increasing prevalence of CRE in the USA and worldwide, several studies have described the epidemiology of CRE in the adult population. While CRE are now also reported sporadically in children, there is a significant lack of data on the epidemiology, risk factors, treatment, and outcomes in this population. This article provides a comprehensive review of what is known to date about CRE, including clinical and molecular epidemiology, microbiologic diagnosis, antibiotic treatment options, and outcomes. In particular, this review will focus on the available data on CRE in the pediatric population.
AB - Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging global public health threat. Infections due to CRE are associated with significant morbidity and mortality. Few therapeutic options are available for treatment of these infections, and optimal antibiotic treatment regimens are unclear. Along with the rapidly increasing prevalence of CRE in the USA and worldwide, several studies have described the epidemiology of CRE in the adult population. While CRE are now also reported sporadically in children, there is a significant lack of data on the epidemiology, risk factors, treatment, and outcomes in this population. This article provides a comprehensive review of what is known to date about CRE, including clinical and molecular epidemiology, microbiologic diagnosis, antibiotic treatment options, and outcomes. In particular, this review will focus on the available data on CRE in the pediatric population.
KW - Carbapenem-resistant Enterobacteriaceae (CRE)
KW - Carbapenemases
KW - Gram-negative
KW - KPCs
KW - Multidrug-resistant organisms
KW - Pediatrics
KW - Resistant gram-negative bacteria
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U2 - 10.1007/s11908-015-0510-9
DO - 10.1007/s11908-015-0510-9
M3 - Review article
C2 - 26711126
AN - SCOPUS:84951869832
SN - 1523-3847
VL - 18
SP - 1
EP - 11
JO - Current Infectious Disease Reports
JF - Current Infectious Disease Reports
IS - 1
M1 - 2
ER -