Carbamazepine levels in pregnancy and lactation

Jennifer R. Niebyl, David A. Blake, John M. Freeman, Ronald D. Luff

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


An epileptic patient whose seizures were controlled with carbamazepine and primidone was followed throughout pregnancy and lactation. Blood levels of primidone decreased during pregnancy and rose postpartum requiring dosage adjustments. Pharmacologically insignificant amounts of the drug were detected in breast milk. A review of the literature revealed 94 infants exposed to carbamazepine in utero and no evidence to date that this drug carries a teratogenic risk.

Original languageEnglish (US)
Pages (from-to)139-140
Number of pages2
JournalObstetrics and gynecology
Issue number1
StatePublished - Jan 1979

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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