Capillary ultrastructure in human metastatic brain tumors

D. M. Long

Research output: Contribution to journalArticlepeer-review

123 Scopus citations


The ultrastructural characteristics of blood vessels within 18 metastatic neoplasms of the brain have been studied. The abnormal permeability to protein-bound tracers was found to be related to defective capillary endothelium. Abnormalities include gap functions, fenestrations of membranes, and open normal junctions. The abnormal capillaries had the character of capillaries from current tissue. Endothelium cell abnormalities were not found in surrounding edematous brain.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalJournal of neurosurgery
Issue number1
StatePublished - Jan 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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